Evidence map›Paper›PMID 40311776›Full record

Trial reportThe Annals of thoracic surgery2025

Perioperative Normoxia vs Hyperoxia in Neonates With Cyanotic Heart Disease Undergoing Cardiac Surgery: A Randomized Controlled Trial.

Nathaniel Sznycer-Taub, Yun-Wen Peng, Sunkyung Yu, Adriana Batazzi, Andrea Les, Ray Lowery, Kevin Griffith, David Sturmer, Richard G Ohye, Mark W Russell and 2 more

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Annals of thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nathaniel Sznycer-TaubDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan. Electronic address: nsznycer@med.umich.edu.
Yun-Wen PengDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Sunkyung YuDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Adriana BatazziDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Andrea LesDepartment of Perfusion, Department of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.
Ray LoweryDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Kevin GriffithDepartment of Perfusion, Department of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.
David SturmerDepartment of Perfusion, Department of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.
Richard G OhyeSection of Pediatric Cardiovascular Surgery, Department of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.
Mark W RussellDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Sara K PasqualiDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
John CharpieDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
NCATS NIH HHS UL1 TR002240
6 · The paper itself

Abstract

backgroundExposure to supraphysiologic levels of oxygen has been associated with end-organ damage and worse outcomes across multiple populations related to oxidative stress and inflammation. There is limited evidence to guide practice in children undergoing surgery with cardiopulmonary bypass, including neonates with cyanotic congenital heart disease, who are particularly vulnerable to oxidative stress due to immature and depleted antioxidant defenses.

methodsWe conducted a randomized trial of perioperative normoxia (goal PaO

resultsTwenty-nine neonates (median age, 5 days) were enrolled. Mean PaO

conclusionsControlled normoxia during cardiopulmonary bypass in cyanotic neonates is feasible, safe, and associated with significant improvement in measures of oxidative stress. These data are critical in informing larger-scale studies of end-organ injury and clinical outcomes.

Indexed as

Cardiac Surgical ProceduresCardiopulmonary BypassCyanosisHeart Defects, CongenitalHyperoxiaOxygenPerioperative CareFemaleHumansInfant, NewbornMaleOxidative StressOxygen

Identifiers

PMID40311776
PMCPMC12353487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.