ArticleNMR in biomedicine2025
MR Imaging of Pulmonary Surfactant Distribution in a Preclinical Neonatal Lung Model.
Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Pulmonary Pharmacokinetics/Pharmacodynamics of Commonly Used Antibiotics in the Treatment of Community-Acquired Pneumonia.European journal of drug metabolism and pharmacokinetics · 2026Review
- Preclinical Quantitative In Vivo MRI Assessment of Exogenous Surfactant Pulmonary Distribution After Clinically Relevant Intratracheal Delivery.NMR in biomedicine · 2026Article
- Characterization of atomization and delivery efficiency of exogenous surfactant in preterm infant lungs using an ex vivo respiratory model.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The administration of exogenous surfactant is essential for many premature infants to compensate for pulmonary immaturity and the absence of endogenous surfactant at birth. Exogenous surfactant delivery techniques are continually being refined to improve the management of these infants, with the goal of increasing therapeutic efficacy and decreasing the invasiveness of delivery protocols. Imaging is one of the tools available to achieve these goals. In this study, we established and applied an magnetic resonance imaging (MRI) protocol in a rabbit animal model to determine the intrapulmonary distribution of surfactant solution administered by the clinical reference method. The protocol was applied to an ex vivo model of isolated thorax from non-valued food industry by-products. The protocol made it possible to image surfactant biodistribution with isotropic spatial resolution in the millimeter range, to determine surfactant distribution between the main airways and distal lung regions where alveoli are present using automated segmentation techniques, and to quantitatively map the distribution of the administered surfactant solution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.