ArticleCell2025
tRNA modifications tune m
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
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Who cites it
24 citing papers in PubMed.
- Article
- The role of RNA modifications in cancer translational control.RNA biology · 2026Review
- mNature reviews. Neuroscience · 2026Review
- Single-molecule mbioRxiv : the preprint server for biology · 2026Article
- RNA modifications in cancer and their detection: a review.Japanese journal of clinical oncology · 2026Review
- CDS-localized mNature plants · 2026Article
- Recognition of the wobble pair: quantum mechanical calculations of tRNA U34 or C34 modifications within the ribosomal decoding center.Nucleic acids research · 2026Article
- Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance.Nature communications · 2026Article
- Unravelling Multilayered RNA Modification Networks in Female Reproduction and Obstetric/Gynaecologic Disorders.Biomolecules · 2026Review
- m6A modified circPTK2 mediates TNBC chemotherapy resistance.Translational cancer research · 2026Article
- Magnesium ions facilitate osteogenic differentiation and intervertebral fusionJournal of orthopaedic translation · 2026Article
- Ribosome-associated quality control and related mechanisms.Nature structural & molecular biology · 2026Review
- High-stoichiometry mRNA (New York, N.Y.) · 2026Article
- Quality control and signaling pathways at stalled ribosomes.Experimental & molecular medicine · 2026Review
- NNature reviews. Cancer · 2026Review
- m6A-Modified Nucleotide Bases Improve Translation of In Vitro-Transcribed Chimeric Antigen Receptor (CAR) mRNA in T Cells.International journal of molecular sciences · 2026Article
- Structural insights into the Urm1-Uba4 pathway and its biological roles.Essays in biochemistry · 2025Review
- Integrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia.Communications biology · 2025Article
- Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants.Nucleic acids research · 2025Article
- Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Bastian LinderGenome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
Puneet SharmaMax-Planck-Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.
Jie WuMax-Planck-Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland; The Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012 Bern, Switzerland; Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Tosca BirbaumerDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland; The Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012 Bern, Switzerland.
Cristian EggersDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.
Shino MurakamiDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
Roman E OttDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.
Kai FenzlGenome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
Hannah VorgerdMax-Planck-Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
Florian ErhardInstitute of Virology and Immunobiology, University of Würzburg, 97078 Würzburg, Germany; Chair of Computational Immunology, University of Regensburg, 93053 Regensburg, Germany.
Samie R JaffreyDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
Sebastian A LeidelMax-Planck-Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland. Electronic address: sebastian.leidel@unibe.ch.
Lars M SteinmetzGenome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany; Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA; Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: larsms@stanford.edu.
Funding
Center for Multi-Scale Analysis of the Human EpitranscriptomeRM1HG011563 · NHGRI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY, Kathryn D Meyer · 2021 to 2026
$22.2MNew mechanisms and technologies for understanding post-transcriptional gene regulation in neuronsR35NS111631 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY · 2019 to 2026
$8.6MUltra-sensitive multi-mode laser-scanning imaging systemS10OD030335 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAFFREY, SAMIE R · 2021 to 2021
$163kNHGRI NIH HHS RM1 HG011563NIH HHS S10 OD030335NINDS NIH HHS R35 NS111631
Abstract
Chemically modified nucleotides in mRNA are critical regulators of gene expression, primarily through interactions with reader proteins that bind to these modifications. Here, we present a mechanism by which the epitranscriptomic mark N
Indexed as
AdenosineRNA, MessengerRNA StabilityRNA, TransferAnimalsCell Line, TumorHumansNeoplasmsProtein BiosynthesisRibosomesRNA Processing, Post-TranscriptionalThiouridineTranscriptomeAdenosineN-methyladenosineRNA, MessengerRNA, TransferThiouridinecancerepitranscriptomem(6)Amcm(5)s(2)UmRNA decaymRNA translationN(6)-methyladenosineoncogenic signalingribosome collisionstRNA modification
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.