Evidence map›Paper›PMID 40311147›Full record

ArticleBiochemistry2025

Redox Homeostasis within the Drug-Resistant Malarial Parasite Digestive Vacuole.

Andreas Willems, Therese Oertel, Paul D Roepe

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Biochemistry · 2026
    Article
  2. Chemical propulsion of hemozoin crystal motion in malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andreas WillemsDepts. of Chemistry and of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, District of Columbia 20057, United States.
Therese OertelDepts. of Chemistry and of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, District of Columbia 20057, United States.
Paul D RoepeDepts. of Chemistry and of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, District of Columbia 20057, United States.ORCID 0000-0002-7079-3793

Funding

The Function of Antimalarial Drug Resistance ProteinsR01AI056312 · NIAID · GEORGETOWN UNIVERSITY · PI PAUL D. ROEPE · 2003 to 2026
$7.5M
Quantifying Redox Potentials for Artemisinin Resistant (ARTR) MalariaR21AI168720 · NIAID · GEORGETOWN UNIVERSITY · PI ROEPE, PAUL D. · 2022 to 2023
$420k
NIAID NIH HHS R01 AI056312NIAID NIH HHS R21 AI168720
6 · The paper itself

Abstract

We have developed a cost-effective strategy for the complete synthesis of azetidinyl coumarin fluorophore derivatives that report changes in physiologic levels of glutathione (GSH), which includes a more cost- effective synthesis of the probe precursor hydroxyl derivative and its subsequent derivatization to promote subcellular localization. We functionalize coumarin derivatives with a cyano side chain similar to a previous strategy (Jiang X. et al.,

Indexed as

AntimalarialsDrug ResistanceMalaria, FalciparumPlasmodium falciparumVacuolesAnimalsChloroquineCoumarinsDextransErythrocytesFluorescent DyesGlutathioneHomeostasisHumansOxidation-ReductionAntimalarialsChloroquineCoumarinsDextransFluorescent DyesGlutathione

Identifiers

PMID40311147
PMCPMC12096432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.