ArticleACS applied bio materials2025
Development of uMUC-1 Targeted NEMO Particles with pH-Activatable MRI Signals for Enhanced Detection of Malignant Breast Cancer Cells.
Dhruvi M Panchal, Alexia R Gorman, Celia Martinez de la Torre, Barrick M Silverman, Anthony J Scalzo, Hunter T Snoderly, Benoit Driesschaert, Margaret F Bennewitz
Abstract read
In one paragraphArticle in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Dhruvi M PanchalDepartment of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, United States.
Alexia R GormanDepartment of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, United States.
Celia Martinez de la TorreDepartment of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, United States.
Barrick M SilvermanDepartment of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, United States.
Anthony J ScalzoDepartment of Biology, Eberly College of Arts and Sciences, West Virginia University, Morgantown, West Virginia 26506, United States.
Hunter T SnoderlyDepartment of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, United States.
Benoit DriesschaertDepartment of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID 0000-0002-1402-413X Margaret F BennewitzDepartment of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID 0000-0002-2519-1603 Funding
West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Stephenie Kay Kennedy-Rea · 2012 to 2026
$81.0MWVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Karen H Martin · 2018 to 2026
$22.4MFinding NEMO's Switchable MRI Signal Using Microfluidic Tumor ModelsR15CA274189 · NCI · WEST VIRGINIA UNIVERSITY · PI BENNEWITZ, MARGARET · 2023 to 2024
$551kNCI NIH HHS R15 CA274189NIGMS NIH HHS P20 GM121322NIGMS NIH HHS U54 GM104942
6 · The paper itselfAbstract
Magnetic resonance imaging (MRI) detects more breast cancers than mammography due to its superior soft tissue contrast; however, it still misdiagnoses 40% of benign tumors as malignant due to clinically used nonspecific contrast agents (e.g., gadolinium chelates). To overcome this limitation, we developed receptor-targeted, pH-sensitive Nano-Encapsulated Manganese Oxide (NEMO) particles as an alternative
Indexed as
Biocompatible MaterialsBreast NeoplasmsContrast MediaMagnetic Resonance ImagingManganese CompoundsMucin-1OxidesCell Line, TumorFemaleHumansHydrogen-Ion ConcentrationMaterials TestingParticle SizeSurface PropertiesBiocompatible MaterialsContrast MediaManganese CompoundsMucin-1Oxidesbreast cancermagnetic resonance imagingmanganese oxidenanoparticlesuMUC-1
Identifiers
PMID40311033
PMCPMC12093376
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