Evidence map›Paper›PMID 40310922›Full record

ArticleScience (New York, N.Y.)2025

Discovery research in physiologically maintained deceased.

Douglas B Pet, Brendan Parent, Neel S Singhal, Claire D Clelland

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Douglas B PetDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Brendan ParentDivision of Medical Ethics, Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Neel S SinghalDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Claire D ClellandDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.

Funding

Resource Core II: In Vivo CoreU19NS132303 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI FYODOR D URNOV · 2023 to 2026
$19.7M
Investigating Donor Authorization and Public Perceptions of Normothermic Regional Perfusion to Inform Ethical Organ Donation PracticesR01HL173157 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Brendan Parent · 2024 to 2026
$2.4M
CRISPR-Cas9 editing in C9orf72 patient derived iPSCK08NS112330 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLELLAND, CLAIRE · 2020 to 2024
$1.2M
Optimization of CRISPR genome editor and its delivery strategy for C9orf72 frontotemporal dementiaU01NS134062 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLELLAND, CLAIRE, GONG, SHAOQIN - · 2023 to 2023
$870k
Transplanting Lungs from Uncontrolled Donation after Circulatory DeathR61HL156890 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MONTGOMERY, ROBERT A, WALL, STEPHEN P · 2022 to 2023
$831k
BLRD VA IK2 BX005369NHLBI NIH HHS R01 HL173157NHLBI NIH HHS R61 HL156890NINDS NIH HHS K08 NS112330NINDS NIH HHS U01 NS134062NINDS NIH HHS U19 NS132303
6 · The paper itself

Abstract

Expanded research opportunities in deceased humans require ongoing ethical inquiry.

Indexed as

Biomedical ResearchDeathOrgan PreservationTissue and Organ ProcurementCadaverHumans

Identifiers

PMID40310922
PMCPMC12309407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.