ArticleThe journal of physical chemistry letters2025
The Properties That Allow Tuning the Reduction Potentials over a Volt Range in Biological Iron/Sulfur Clusters.
Article in The journal of physical chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Geometry, spin coupling, and dielectric control of redox potentials in [4Fe-4S] Clusters.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Probing the Role of Accessory FeS Clusters in Putative Sensory Group D [FeFe] Hydrogenase: Influence of the C-Terminal [4Fe-4S] Cluster on the Reactivity ofBiochemistry · 2026Article
- Predicting Metalloprotein Redox Potentials with Machine Learning: A Focus on Iron-Sulfur Systems.Journal of chemical information and modeling · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
[4Fe-4S] clusters are ubiquitous in biology and are crucial to the more salient processes in energy metabolism, serving as intermediates in inter- and intramolecular electron transfer pathways. The [4Fe-4S] clusters are more prevalent, serving a variety of functions, and can remarkably adopt a surprising range of reduction potentials spanning more than 1 V. The characteristics of the environment, including charge, solvent access, and geometric distortion, finely modulate the reduction potential of iron/sulfur clusters. However, prior research has not yet systematically addressed cause and effect. In this work, we conducted a thorough theoretical assessment of how charge distribution and structural distortion contribute to the full range of reductions exhibited by biological [4Fe-4S] clusters. The work shows that the most significant contributions can be predicted for electrostatic interactions, which are directionally biased.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.