Evidence map›Paper›PMID 40310601›Full record

ArticleJournal of behavioral medicine2025

Everyday discrimination and subclinical indicators of stroke in midlife women.

Jennifer B Wells, Natalie Egnot, Emma Barinas-Mitchell, Maria M Brooks, Dara D Mendez, Rebecca C Thurston

Abstract read
In one paragraph

Article in Journal of behavioral medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer B WellsDepartment of Epidemiology, University of Pittsburgh, 130 N. Bellefield Ave, Pittsburgh, PA, 15213, USA.
Natalie EgnotStantec, Pittsburgh, PA, USA.
Emma Barinas-MitchellDepartment of Epidemiology, University of Pittsburgh, 130 N. Bellefield Ave, Pittsburgh, PA, 15213, USA. ejb4@pitt.edu.ORCID 0000-0002-7280-7781
Maria M BrooksDepartment of Epidemiology, University of Pittsburgh, 130 N. Bellefield Ave, Pittsburgh, PA, 15213, USA.
Dara D MendezDepartment of Epidemiology, University of Pittsburgh, 130 N. Bellefield Ave, Pittsburgh, PA, 15213, USA.
Rebecca C ThurstonDepartment of Epidemiology, University of Pittsburgh, 130 N. Bellefield Ave, Pittsburgh, PA, 15213, USA.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Menopausal Vasomotor Symptoms and Brain Aging in WomenRF1AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2016 to 2019
$4.1M
Menopausal Vasomotor Symptoms and Brain Aging in WomenR01AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2021 to 2025
$3.8M
Mechanisms linking hot flashes to cardiovascular riskR01HL105647 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2011 to 2015
$3.2M
Interdisciplinary Mentoring and Research in Womens Cardiovascular HealthK24HL123565 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2014 to 2023
$1.0M
API 4000 QTRAPS10RR023461 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLOYAC, SAMUEL M · 2007 to 2007
$487k
Small Molecule Biomarker Core: TSQ Altis LC-MS/MSS10OD028540 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NOLIN, THOMAS DOUGLAS · 2020 to 2020
$429k
NCATS NIH HHS UL1 TR000005NCRR NIH HHS S10 RR023461NHLBI NIH HHS 2K24123565NHLBI NIH HHS K24 HL123565NHLBI NIH HHS R01 HL105647NHLBI NIH HHS R01HL105647NIA NIH HHS R01 AG053504NIA NIH HHS RF1 AG053504NIH HHS S10 OD028540University of Pittsburgh Clinical and Translational Science Institute UL1TR000005
6 · The paper itself

Abstract

Disparities between Black and White women in stroke risk in the United States are present during midlife, a period during which subclinical indicators of stroke risk accelerate in women. Racism and forms of discrimination have long been associated with cardiovascular pathophysiology. However, few studies have examined midlife discrimination among women and subclinical carotid atherosclerosis, a strong predictor of stroke and myocardial infarction. The Everyday Discrimination Scale, which measures discriminatory experiences, was administered to 304 (including 120 White and 76 Black) midlife women (mean age = 54, SD = 3.9) free of clinical cardiovascular disease. At the same visit, using ultrasonography, we measured four markers of subclinical carotid atherosclerosis, including plaque count, grey scale median, and maximum plaque height. The majority (85%) of women experienced at least one form of discrimination in their daily life. Black women reported experiencing greater discrimination than White women with a mean (SD) Everyday Discrimination Score of 7.3 (5.2) versus 5.7 (4.3). These experiences were most attributed to race, age, income, and "other." Black participants had a higher prevalence of carotid plaque compared to White participants (52% versus 46%). Using Poisson regression, higher discrimination was associated with higher plaque count among Black women only, adjusted for age, systolic blood pressure, low-density lipoprotein cholesterol, and education, such that one standard deviation increase in the Everyday Discrimination Scale was associated with a 25% higher plaque count. Further adjusting for financial strain did not reduce the effect size. We did not observe an association between discrimination and other carotid plaque measures in Black or White women. In Black women, higher levels of discrimination was associated with greater carotid atherosclerosis. Clarifying the relationship between discrimination and subclinical indicators of stroke risk could inform social and healthcare interventions to reduce discrimination and potential associated stroke risk.

Indexed as

Carotid Artery DiseasesRacismStrokeAdultBlack or African AmericanFemaleHumansMiddle AgedPlaque, AtheroscleroticRisk FactorsUnited StatesWhiteAtherosclerosisCarotid plaqueDiscriminationMidlifeRace and ethnicityWomen’s health

Identifiers

PMID40310601
PMCPMC12307120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.