Evidence map›Paper›PMID 40310599›Full record

ArticleCell biochemistry and biophysics2025

Elucidating the Phytochemical, Antibacterial, and Hepatoprotective Effects of Elaeagnus umbellata Leaf Extract Against Liver Injury in an Animal Model.

Nausheen Nazir, Sajid Khan, Nasiara Karim, Mohammad Nisar, Tariq Aziz, Ashwag Shami, Fahad Al-Asmari, Areej A Alhhazmi, Fakhria A Al-Joufi, Maher S Alwethaynani

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Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nausheen NazirDepartment of Biochemistry, University of Malakand, Chakdara, Dir (Lower), Khyber Pakhtunkhwa, Pakistan. nausheen.nazir@uom.edu.pk.
Sajid KhanDepartment of Biochemistry, University of Malakand, Chakdara, Dir (Lower), Khyber Pakhtunkhwa, Pakistan.
Nasiara KarimDepartment of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Peshawar, Pakistan.
Mohammad NisarDepartment of Botany, University of Malakand, Chakdara, Dir (Lower), Khyber Pakhtunkhwa, Pakistan.
Tariq AzizLaboratory of Animal Health Food Hygiene and Quality, University of Ioannina, Arta, Greece. iwockd@gmail.com.
Ashwag ShamiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Fahad Al-AsmariDepartment of Food and Nutrition Sciences, College of Agricultural and Food Sciences, King Faisal University, Al Ahsa, Saudi Arabia.
Areej A AlhhazmiClinical Laboratory Sciences Department. Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.
Fakhria A Al-JoufiDepartment of Pharmacology, College of Pharmacy, Jouf University, Aljouf, Saudi Arabia.
Maher S AlwethaynaniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Alquwayiyah, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elaeagnus umbellata, commonly known as autumn olive, is considered a medicinal plant of high value and belongs to the Elaeagnaceae family. It exhibits anti-ulcer, antimutagenic, antimicrobial, and neuroprotective properties. The leaves of E. umbellata reportedly have pharmacological activities, including antibacterial, anti-inflammatory, and anticancer effects. However, no in vivo studies have evaluated this plant's hepatoprotective potential. In this study, the hepatoprotective potential of E. umbellata was determined using an in vivo model. Extraction from the leaves of E. umbellata was carried out using standard methods, which then were subjected to gas chromatography and mass spectroscopy for characterization. Fourteen compounds were identified in the crude methanolic extract (Met-Ext) of E. umbellata leaves. Total phenolic and total flavonoid contents were assessed, and the extract was tested for hepatoprotective potential against carbon tetrachloride (CCL

Indexed as

Anti-Bacterial AgentsChemical and Drug Induced Liver InjuryElaeagnaceaeLiverPhytochemicalsPlant ExtractsPlant LeavesProtective AgentsAnimalsCarbon TetrachlorideDisease Models, AnimalFlavonoidsMalePhenolsRatsRats, WistarAnti-Bacterial AgentsCarbon TetrachlorideFlavonoidsPhenolsPhytochemicalsPlant ExtractsProtective AgentsBacterial strainsCCl4Elaeagnus umbellateGC-MSLipid profileLiver parametersSilymarinTFCTPC

Identifiers

PMID40310599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.