Evidence map›Paper›PMID 40310563›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2025

Fibroblast activation protein-targeted PET/CT with

Yangchun Chen, Lingyu Yu, Shiju Chen, Wen Liu, Haiwei Han, Yizhen Pang, Qingyan Lin, Yan Li, Liying Chen, Jiayu Cai and 5 more

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05999643 (Characterizing Spondyloarthritis With 68Ga-FAPI PET/CT), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05999643 naunknown statusnot on this map

Characterizing Spondyloarthritis With 68Ga-FAPI PET/CT

TypeinterventionalSponsorThe First Affiliated Hospital of Xiamen UniversityRan2023 to 2025Enrolled50ConditionsSpondyloarthritis, Axial Spondyloarthritis, Ankylosing SpondylitisArmsDrug: 68Ga-FAPI
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. A scoping review on potential of novel developments in fever of unknown origin and inflammation of unknown origin: long-axial-field-of-view positron emission tomography/computed tomography and novel radiotracers.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yangchun Chen *Department of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China.
Lingyu Yu *Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.
Shiju ChenDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China.
Wen LiuDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China.
Haiwei HanDepartment of Radiology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Yizhen PangDepartment of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.
Qingyan LinDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China.
Yan LiDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China.
Liying ChenDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China.
Jiayu CaiDepartment of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.
Liang ZhaoDepartment of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.
Long SunDepartment of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.
Guixiu ShiDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China. gshi@xmu.edu.cn.
Haojun ChenDepartment of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China. leochen0821@foxmail.com.ORCID 0000-0002-9101-8884
Yuan LiuDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Rd. 55, Xiamen, XM, 361000, China. liuyuan@xmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAxial spondyloarthritis (axSpA) is characterized by active inflammation and structural damage. To date, there is no imaging tool can alone visualize all those changes well. PET/CT imaging with gallium-68-labeled fibroblast activation protein inhibitor (

methodsBetween July 2023 to July 2024, 22 patients with axSpA and 12 healthy volunteers were prospectively enrolled. Disease activity and parameters associated with inflammation were evaluated at enrollment. Participants then underwent

resultsCompared to healthy volunteers, patients with axSpA exhibited significantly higher

conclusionCLINICAL

trial registrationNCT05999643.

Indexed as

Axial SpondyloarthritisPositron Emission Tomography Computed TomographyAdultEndopeptidasesFemaleFibroblast Activation Protein AlphaGallium IsotopesGallium RadioisotopesHumansInflammationMaleMembrane ProteinsMiddle AgedProspective StudiesQuinolines68Ga-FAPIEndopeptidasesFibroblast Activation Protein AlphaGallium IsotopesGallium RadioisotopesMembrane ProteinsQuinolinesAxial spondyloarthritisDisease activityFibroblast activation proteinPET/CT

Identifiers

PMID40310563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.