ArticleMolecular biology reports2025
Predicted risk genotypes to cardiovascular diseases based on cholesterol ester transfer protein (CETP -rs708272) and lipoprotein lipase (LPL -rs13702) variants in worldwide populations: highest risk in populations with Native American ancestry.
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Abstract
backgroundThe human genetic variability mainly involves single nucleotide variants (SNVs) that determine the characteristics among individuals. Some gene variants related to the lipid metabolism have demonstrated their importance to generate susceptibility to some metabolic diseases, such as those in the Cholesterol Ester Transfer Protein (CETP) and Lipoprotein Lipase (LPL) genes. METHODS AND
resultsWe analyzed the variants rs708272 and rs13702 of the CETP and LPL genes in 540 Mexican Mestizos (admixed) and Mexican Native Americans, respectively. The SNVs were analyzed by qPCR with TaqMan probes. The GeneAlex 6.0, GDA 1.1, and Arlequin 3.0 softwares were used for statistical analysis.
resultsGenotype and allele frequencies for these variants in the CETP and LPL genes were estimated. The Analysis of Molecular Variance (AMOVA) including Mexican and worldwide populations from the 1000 genomes project, demonstrated significant genetic heterogeneity for both variants (p-value < 0.0001). Based on previous association studies, we predicted the genetic risk to cardiovascular diseases in global populations using combined high-risk allele frequencies (TT + TT), whose prevalence was larger in Native Americans than Mestizos (21.6 vs 11.7%; p = 0. 044). Globally, Peru showed the largest prevalence (21%) and African populations the lowest (1%).
conclusionBased on the rs13702 and rs708272 gene variants, the highest predicted genetic risk levels for cardiovascular diseases is related to populations with high Native American ancestry, such as those from Latin America, especially when combined with obesogenic habits. Understanding genetic distribution of these variants in Mexican population could suggest an integral intervention for the management of cardiovascular diseases.
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