SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Diagnostic potential of biomarkers in the assessment of pediatric obstructive sleep apnea-A systematic review and meta- analysis.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Peripheral Mononuclear Cells Metabolomics in Obstructive Sleep Apnea Syndrome (OSAS): An Exploratory Pilot Study of Immunometabolic Signatures.International journal of molecular sciences · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePeriodic hypopnea or apnea during sleep, along with episodes of hypoxia and sleep fragmentation caused by frequent awakenings to restore the upper airway are the characteristics of Pediatric obstructive sleep apnea (P-OSA). While extensive literature evaluates biomarkers in the diagnosis of OSA in adults, no systematic review summaries their diagnostic accuracy in P-OSA. This systematic review evaluates the diagnostic accuracy of biomarkers in assessing the P-OSA compared to Polysomnography in children.
methodThe research question was established in PECO format. The study protocol was registered in PROSPERO. A literature search was conducted in various database upto January 2025, including studies that assessed various biomarkers in comparison with polysomnography. Screening was done with Distiller SR and the risk of bias was assessed with Newcastle-Ottawa Scale. Meta-analysis was performed with the pooled sensitivity and specificity values using RevMan software.
resultsEighteen studies were included, that assessed transfer-ribonucleic acid, C-reactive protein, inflammatory markers, leukotrienes, salivary amylase, salivary cortisol, isoprostane and hydrogen peroxide. Meta-analysis revealed that urine-based biomarkers had highest diagnostic accuracy with a sensitivity of 89.75%, compared to 77.87% for serum-based biomarkers. The pooled Odds ratio was 10.31 (95% CI: 8.48-12.54), indicating a strong diagnostic association.
conclusionBiomarkers offer a non- invasive and reliable diagnostic tool for P-OSA. Urine-based leukotriene biomarkers are a promising biomarkers for screening P-OSA in conjunction with other diagnostic aids, due to its high sensitivity. However, the diagnostic accuracy can be influenced by various factors, necessitating further studies to identify biomarkers with high precision in the diagnosis of P-OSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.