Evidence map›Paper›PMID 40310491›Full record

ArticleEuropean radiology experimental2025

AI-augmented reconstruction provides improved image quality and enables shorter breath-holds in contrast-enhanced liver MRI.

Francesca Castagnoli, Mihaela Rata, Joshua Shur, Georgina Hopkinson, Alison Macdonald, David Stockton, Marcel Dominik Nickel, Stephan Kannengiesser, Christina Messiou, Dow-Mu Koh and 1 more

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Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Francesca Castagnoli *Department of Radiology, Royal Marsden Hospital, London, UK. francesca.castagnoli@rmh.nhs.uk.ORCID http://orcid.org/0000-0003-2407-7451
Mihaela Rata *Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.
Joshua ShurDepartment of Radiology, Royal Marsden Hospital, London, UK.
Georgina HopkinsonDepartment of Radiology, Royal Marsden Hospital, London, UK.
Alison MacdonaldDepartment of Radiology, Royal Marsden Hospital, London, UK.
David StocktonDepartment of Radiology, Royal Marsden Hospital, London, UK.
Marcel Dominik NickelMR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany.
Stephan KannengiesserMR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany.
Christina MessiouDepartment of Radiology, Royal Marsden Hospital, London, UK.
Dow-Mu KohDepartment of Radiology, Royal Marsden Hospital, London, UK.
Jessica Mary WinfieldDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare liver image quality and lesion detection using an AI-augmented T1-weighted sequence on hepatobiliary-phase gadoxetate-enhanced magnetic resonance imaging (MRI).

methodsFifty patients undergoing gadoxetate-enhanced MRI were recruited. Two T1-weighted Dixon sequences were utilized: a 17-s breath-hold acquisition and an accelerated 12-s breath-hold acquisition (reduced phase resolution), both reconstructed using neural network (NN) and iterative denoising (ID), NN-alone, ID-alone, and the standard method. Contrast-to-noise ratio (CNR) was assessed quantitatively for all series (ANOVA). Two blinded radiologists independently analyzed three image sets: 17-s acquisition reconstructed with NN and ID (17-s NN + ID), 12-s acquisition reconstructed with NN and ID (12-s NN + ID), and 17-s acquisition with standard reconstruction (17-s standard). Overall image quality, qualitative CNR, lesion edge sharpness, vessel edge sharpness, and respiratory motion artifacts were scored (4-point Likert scale) and compared (Friedman test). Lesion detection was compared between 12-s NN + ID and 17-s standard reconstructions (Wilcoxon signed-rank test).

resultsQuantitative liver-to-portal vein CNR was significantly higher for 17-s NN + ID than 17-s standard or 17-s NN-alone images (p = 0.001). Scores for overall image quality, qualitative CNR, vessel edge sharpness, and lesion edge sharpness were significantly higher for 17-s NN + ID and 12-s NN + ID than standard reconstruction (p < 0.001); there was no significant difference between 17-s and 12-s NN + ID. There was no significant difference in respiratory motion artifacts and number of lesions or diameter of the smallest detected lesion using 12-s NN + ID or 17-s standard reconstruction.

conclusionAI-augmented reconstructions can improve image quality while reducing breath-hold duration in T1-weighted hepatobiliary-phase gadoxetate-enhanced MRI, without compromising lesion detection. RELEVANCE STATEMENT: AI-augmented reconstruction of T1-weighted MRI improves image quality and lesion detection in hepatobiliary phase liver imaging, reducing breath-hold duration without compromising clinical lesion detection. KEY POINTS: Liver-to-portal vein CNR was significantly higher for 17-s NN + ID. AI-augmented reconstructions scored higher for image quality, contrast-to-noise, vessel-edge, and lesion-edge sharpness. No significant difference in lesion detection between 12-s NN + ID and 17-s standard reconstructions.

Indexed as

Breath HoldingContrast MediaGadolinium DTPAImage Processing, Computer-AssistedLiverLiver NeoplasmsMagnetic Resonance ImagingNeural Networks, ComputerAdultAgedFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAArtifacts, Artificial intelligenceLiver neoplasms, Magnetic resonance imaging, Neural networks (computer)

Identifiers

PMID40310491
PMCPMC12045906

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.