Evidence map›Paper›PMID 40310468›Full record

ArticleMicrobial genomics2025

Gene conversion and duplication contribute to genetic variation in an outbreak of

Christoph Stritt, Michelle Reitsma, Ana Maria Garcia Marin, Galo Goig, Anna Dötsch, Sonia Borrell, Christian Beisel, Iñaki Comas, Daniela Brites, Sebastien Gagneux

Abstract read
In one paragraph

Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Gene conversion is a key driver of diversity hotspots inbioRxiv : the preprint server for biology · 2026
    Article
  4. Heteroresistance inFrontiers in cellular and infection microbiology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis ofmedRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christoph StrittSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Michelle ReitsmaSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Ana Maria Garcia MarinBiomedicine Institute of Valencia, Spanish Research Council (IBV-CSIC), Valencia, Spain.
Galo GoigSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Anna DötschSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Sonia BorrellSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Christian BeiselDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Iñaki ComasBiomedicine Institute of Valencia, Spanish Research Council (IBV-CSIC), Valencia, Spain.
Daniela BritesSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Sebastien GagneuxSwiss Tropical and Public Health Institute, Allschwil, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeats are the most diverse and dynamic but also the least well-understood component of microbial genomes. For all we know, repeat-associated mutations such as duplications, deletions, inversions and gene conversion might be as common as point mutations, but because of short-read myopia and methodological bias, they have received much less attention. Long-read DNA sequencing opens the perspective of resolving repeats and systematically investigating the mutations they induce. For this study, we assembled the genomes of 16 closely related strains of the bacterial pathogen

Indexed as

Gene ConversionGene DuplicationGenetic VariationMycobacterium tuberculosisTuberculosisDisease OutbreaksGenome, BacterialHumansPhylogenySequence Analysis, DNAlong-read sequencingpangenome graphPE/PPE genesphylogenetic resolutionrecombinationrepeats

Identifiers

PMID40310468
PMCPMC12046097

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.