Evidence map›Paper›PMID 40310457›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Global modulation of gene expression and transcriptome size in aneuploid combinations of maize.

Hua Yang, Vincent Brennan, Zhi Gao, Jian Liu, Frimpong Boadu, Jianlin Cheng, James A Birchler

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hua YangDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.ORCID 0000-0002-9796-5663
Vincent BrennanDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.
Zhi GaoDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.
Jian LiuDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211.
Frimpong BoaduDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211.
Jianlin ChengDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211.ORCID 0000-0003-0305-2853
James A BirchlerDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.ORCID 0000-0003-3643-2756

Funding

NSF (NSF) IOS-1545780
6 · The paper itself

Abstract

Genomic imbalance refers to the more severe phenotypic consequences of changing a single chromosome compared to changing the whole genomic set. Previous genomic imbalance studies in maize have identified gene expression modulation in aneuploids of single chromosome arms. Here, the modulation of gene expression in more complex aneuploids, e.g., monosomy of one chromosome arm and trisomy of another was examined to determine the extent that combination aneuploids were additive, multiplicative, or rebalanced in terms of their effect on gene expression. A series of genetic crosses was performed to produce one, two, and three copies of one arm with independent one, two, and three copies of the other arm in each of the three genotypes for the opposite arm. In total, 31 combinations were analyzed. By examining RNA modulation, we found that

Indexed as

AneuploidyGene Expression Regulation, PlantTranscriptomeZea maysChromosomes, PlantDosage Compensation, Geneticaneuploidydosage compensationgene balancegene dosage effectsinverse effect

Identifiers

PMID40310457
PMCPMC12067209

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.