Evidence map›Paper›PMID 40310313›Full record

ReviewJACC. Clinical electrophysiology2025

In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging.

Nilesh Mathuria, Krithik Vishwanath, Blake C Fallon, Antonio Martino, Giorgio Brero, Richard C Willson, Miguel Valderrabano, Carly S Filgueira, Richard R Bouchard

Abstract readReview
In one paragraph

Review in JACC. Clinical electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nilesh MathuriaHouston Methodist Heart and Vascular Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA.
Krithik VishwanathDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Blake C FallonDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA.
Antonio MartinoDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA; Department of Materials Science and Engineering, University of Houston, Houston, Texas, USA.
Giorgio BreroDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA; Department of Electronics, Politecnico di Torino, Torino, Italy.
Richard C WillsonDepartment of Biochemical & Biophysical Sciences, University of Houston, Houston, Texas, USA.
Miguel ValderrabanoHouston Methodist Heart and Vascular Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA.
Carly S FilgueiraDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA; Department of Cardiovascular Surgery, Houston Methodist Research Institute, Houston, Texas, USA. Electronic address: csfilgueira@houstonmethodist.org.
Richard R BouchardDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA. Electronic address: rrbouchard@mdanderson.org.

Funding

Molecular Photoacoustic Imaging for Diagnostics and Therapy MonitoringR01EB028762 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BOUCHARD, RICHARD R. · 2020 to 2024
$3.1M
Photoacoustic Imaging to Guide Catheter Ablation of Cardiac ArrhythmiasR21HL159534 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI MATHURIA, NILESH · 2022 to 2023
$453k
NHLBI NIH HHS R21 HL159534NIBIB NIH HHS R01 EB028762
6 · The paper itself

Abstract

Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (<0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.

Indexed as

Catheter AblationPhotoacoustic TechniquesAnimalsModels, AnimalSwineUltrasonographycatheter ablationphotoacoustic imagingradiofrequency ablationultrasoundventricular tachycardia

Identifiers

PMID40310313
PMCPMC12276966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.