Evidence map›Paper›PMID 40310106›Full record

ReviewChildren (Basel, Switzerland)2025

Advancing Pediatric Surgery with Indocyanine Green (ICG) Fluorescence Imaging: A Comprehensive Review.

Marco Di Mitri, Annalisa Di Carmine, Benedetta Zen, Edoardo Collautti, Cristian Bisanti, Simone D'Antonio, Michele Libri, Tommaso Gargano, Mario Lima

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marco Di MitriPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-0392-579X
Annalisa Di CarminePediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.ORCID 0009-0007-0666-6515
Benedetta ZenPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Edoardo CollauttiPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Cristian BisantiPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.ORCID 0009-0008-1708-3814
Simone D'AntonioPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Michele LibriPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Tommaso GarganoPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Mario LimaPediatric Surgery Department, IRCCS Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5877-440X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndocyanine green (ICG) fluorescence imaging has revolutionized pediatric surgery by enhancing precision, safety, and outcomes across various specialties. In recent years, its use has spread through the framework of pediatric surgery, where its ability to illuminate anatomical structures and pathological conditions has improved surgical outcomes.

methodsWe conducted a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search was performed using the term "Indocyanine green" in all fields, including papers about pediatric patients (aged 0-18 years) published between January 2014 and July 2024.

resultsThis review systematically explores ICG applications, dosing regimens, timing of administration, and integration into modern surgical technologies, including robotics and minimally invasive platforms. ICG resulted in an excellent safety profile and enables the real-time visualization of anatomical structures and pathological conditions, proving invaluable in pediatric cases characterized by smaller anatomical dimensions and congenital anomalies.

conclusionsThis review highlights ICG fluorescence imaging as an indispensable tool in pediatric surgery, offering transformative potential for improving surgical outcomes and patient safety. Despite its advantages, it is necessary to standardize dosing and timing protocols to maximize its utility. The aim of this review is to explore the various applications of ICG in pediatric surgery, report the dosage and administration times across different surgical fields, and establish best practices to guide its future use.

Indexed as

ICGindocyanine green fluorescencelaparoscopyminimally invasive surgerypediatric surgeryrobotic surgery

Identifiers

PMID40310106
PMCPMC12026291

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.