ArticleChildren (Basel, Switzerland)2025
Diaphragm Thickness and Contraction During Non-Invasive Ventilation: An Ultrasound Study.
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evolution of diaphragmatic thickness and function in preterm infants on non-invasive neurally adjusted ventilatory assist.European journal of pediatrics · 2026Observational
- Functional Assessment of the Neonatal Diaphragm Using Point-of-Care Ultrasound: A Review of Techniques, Clinical Applications, and Challenges.CHEST pulmonary · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNon-invasive ventilation (NIV) is a widely used treatment for neonatal respiratory distress syndrome (RDS). Data on diaphragm contractility and thickness during NIV is scarce. We aimed to describe changes in diaphragm thickness/contractility during NIV and to explore associations with NIV discontinuation failure.
methodsThis is a single-center prospective study. Diaphragmatic ultrasound was performed weekly during NIV, then within 7 days from NIV discontinuation. Diaphragm thickness was measured at end-inspiration (DTI) and end-expiration (DTE). Diaphragm thickening fraction (DTF) was calculated as (DTI-DTE/DTE). The clinical characteristics of patients and NIV discontinuation failure were recorded. Univariate analysis, logistic regression and linear regression were performed to describe diaphragm features during NIV and associations with NIV discontinuation failure.
resultsWe studied 17 NIV cycles (median duration 21 days). Median DTE increased from 0.12 cm (SD 0.05) at the start of NIV to 0.15 cm (SD 0.04) at NIV discontinuation. The mean DTF decreased from 32.8 (SD 16.8) at the start of NIV to 25.6 (SD 8.9) at NIV discontinuation. NIV discontinuation failure occurred in 23.5% of infants and was associated with higher DTI and DTE at the start of NIV and with a more pronounced decrease in DTI and DTE over the NIV cycle, compared to infants with NIV discontinuation success. There were no differences in neonatal outcomes between the infants with NIV discontinuation failure vs. success. We did not find any significant predictors of NIV failure.
conclusionsDiaphragm thickness increased, whereas DTF decreased over time on NIV in preterm infants with RDS. NIV duration was not associated with changes in diaphragm trophism. NIV discontinuation failure was associated with thicker diaphragm at the start of NIV, as well as with a reduction in diaphragm trophism over the NIV cycle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.