Evidence map›Paper›PMID 40310042›Full record

ReviewChildren (Basel, Switzerland)2025

Systematic Review on Microtia: Current Knowledge and Future Directions.

Filippo Hellies, Silvia Fracaro, Gino Marioni, Annalisa Trotta, Martina Todesco, Martina Casarin, Andrea Bagno, Elisabetta Zanoletti, Giovanna Albertin, Laura Astolfi

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Filippo HelliesBioacoustics Research Laboratory, Department of Neuroscience-DNS, University of Padova, 35128 Padova, Italy.ORCID 0009-0000-7245-5176
Silvia FracaroBioacoustics Research Laboratory, Department of Neuroscience-DNS, University of Padova, 35128 Padova, Italy.ORCID 0009-0009-1386-0724
Gino MarioniPhoniatrics and Audiology Unit, Department of Neuroscience-DNS, University of Padova, 31100 Treviso, Italy.ORCID 0000-0001-8751-0588
Annalisa TrottaBioacoustics Research Laboratory, Department of Neuroscience-DNS, University of Padova, 35128 Padova, Italy.
Martina TodescoDepartment of Industrial Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy.ORCID 0000-0002-4906-5257
Martina CasarinDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Giustiniani 2, 35128 Padova, Italy.ORCID 0000-0002-8212-1484
Andrea BagnoDepartment of Industrial Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy.ORCID 0000-0002-4296-3601
Elisabetta ZanolettiSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience-DNS, "Azienda Ospedale Università di Padova"-University of Padova, 35128 Padova, Italy.
Giovanna AlbertinSection of Human Anatomy, Department of Neuroscience-DNS, University of Padova, Via Gabelli 65, 35122 Padova, Italy.ORCID 0000-0002-7551-4431
Laura AstolfiBioacoustics Research Laboratory, Department of Neuroscience-DNS, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-3291-8567

Funding

University of Padua 2024DNS1DOR-00973
6 · The paper itself

Abstract

backgroundMicrotia is a congenital outer ear deformity that causes the auricle to be absent or underdeveloped. It is frequently associated with external auditory canal atresia and causes hearing and psychosocial problems.

objectivesWe thoroughly investigate the aspects of microtia and explore both current and innovative therapies.

methodsA systematic literature review was conducted following PRISMA guidelines, focusing on microtia and reconstruction methodologies. This review utilized three databases: PubMed, Scopus, and Web of Science.

resultsThe etiology involves both genetic and environmental factors and can occur as part of a syndrome or as an isolated condition. Clinically, it has esthetic and functional implications, potentially leading to conductive hearing loss. A multidisciplinary approach is essential for treatment, which includes surgical reconstruction using autologous cartilage or synthetic prostheses. Advances in bioengineering and 3D printing offer new, less invasive solutions.

conclusionsThis review aims to synthesize current knowledge on microtia, focusing on tissue engineering for auricular reconstruction, identifying research gaps, evaluating techniques, and providing a resource for clinicians to improve decision-making and foster further research.

Indexed as

3D printingauricular reconstructionautologous cartilagecongenital deformitysurgical reconstructionsynthetic prosthesestissue engineering

Identifiers

PMID40310042
PMCPMC12026268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.