Evidence map›Paper›PMID 40309951›Full record

ArticleACS nano2025

Stable and Highly Steerable Magnetic Nanorobots Demonstrate Therapeutical Functionality in Crowded Biological Media.

Jyotiprakash Behera, Suvra S Laha, Debayan Dasgupta, Sayanta Goswami, Souravi Mukherjee, Ankur Jaiswar, Paramita Modak, Mallar Banerjee, Reshma V Ramachandran, Konstantin I Morozov and 4 more

Abstract read
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jyotiprakash BeheraCentre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.
Suvra S LahaCentre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.
Debayan DasguptaCentre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.ORCID 0000-0002-2834-7837
Sayanta GoswamiDepartment of Physics, Indian Institute of Science, Bangalore 560012, India.
Souravi MukherjeeDepartment of Physics, Indian Institute of Science, Bangalore 560012, India.
Ankur JaiswarCentre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.
Paramita ModakCentre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.
Mallar BanerjeeDepartment of Developmental Biology and Genetics, Indian Institute of Science, Bangalore 560012, India.
Reshma V RamachandranDepartment of Bioengineering, Indian Institute of Science, Bangalore 560012, India.
Konstantin I MorozovDepartment of Chemical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.ORCID 0000-0001-7648-4118
Alexander M LeshanskyDepartment of Chemical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.ORCID 0000-0001-9272-8987
Ramray BhatDepartment of Bioengineering, Indian Institute of Science, Bangalore 560012, India.ORCID 0000-0002-5215-9721
Deepak Kumar SainiDepartment of Bioengineering, Indian Institute of Science, Bangalore 560012, India.ORCID 0000-0001-6671-7256
Ambarish GhoshCentre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.ORCID 0000-0002-2524-0014

Funding

DBT-Wellcome Trust India Alliance IA/I/17/2/503312Wellcome TrustWellcome Trust IA/S/19/2/504655
6 · The paper itself

Abstract

Magnetic nanorobots primarily composed of ferromagnetic materials have been extensively investigated for their potential medical applications. Here, we have designed and developed superparamagnetic iron oxide nanoparticles (SPIONs)-functionalized nanorobots (SPIONs-NR), a system that is significantly smaller in size and has larger magnetic anisotropy and steerability than most previously reported superparamagnetic microrobots. We demonstrate that the nanorobots are highly stable against magnetic agglomeration, even at high densities. Due to their smaller size, they can be controllably steered through crowded biological media, which was not possible before. We have maneuvered the robots through the extracellular matrix to target and annihilate malignant cells via magnetic hyperthermia-induced localized heating. Collectively, these properties make SPIONs-NR promising candidates for nanomedicine applications.

Indexed as

Magnetite NanoparticlesCell Line, TumorHumansHyperthermia, InducedParticle SizeRoboticsMagnetite Nanoparticlescolloidal stabilitycrowded mediananorobotssuperparamagnetismtherapeutics

Identifiers

PMID40309951
PMCPMC12080322

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.