Evidence map›Paper›PMID 40309934›Full record

ArticleAddiction biology2025

Acute Alcohol-Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography.

Nakul R Raval, Kelly Smart, Gustavo A Angarita, Rachel Miller, Yiyun Huang, John H Krystal, Richard E Carson, Kelly P Cosgrove, Stephanie S O'Malley, Ansel T Hillmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nakul R RavalYale PET Center, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-5637-7219
Kelly SmartYale PET Center, Yale University, New Haven, Connecticut, USA.
Gustavo A AngaritaYale PET Center, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-5568-9878
Rachel MillerYale PET Center, Yale University, New Haven, Connecticut, USA.
Yiyun HuangYale PET Center, Yale University, New Haven, Connecticut, USA.
John H KrystalDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
Richard E CarsonYale PET Center, Yale University, New Haven, Connecticut, USA.
Kelly P CosgroveDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Stephanie S O'MalleyDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
Ansel T HillmerYale PET Center, Yale University, New Haven, Connecticut, USA.

Funding

Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894k
Mentoring in the Clinical Neuroscience of Alcohol Use DisorderK24AA031345 · NIAAA · YALE UNIVERSITY · PI Kelly P Cosgrove · 2024 to 2026
$631k
NIAAA NIH HHS K01 AA024788NIAAA NIH HHS K01AA024788NIAAA NIH HHS K24 AA031345NIAAA NIH HHS K24AA031345NIAAA NIH HHS P50 AA012870NIAAA NIH HHS P50AA012870State of Connecticut, Department of Mental Health, and Addiction Services for the Clinical Neuroscience Research Unit
6 · The paper itself

Abstract

backgroundAlcohol consumption at clinically relevant doses alters brain glutamate release. However, few techniques exist to measure these changes in humans. The metabotropic glutamate receptor 5 (mGluR5) PET radioligand [

methodsEight social drinkers (25-42 years; 5 females) with a recent drinking occasion achieving a blood alcohol level (BAL) > 80 mg/dL were recruited. All participants underwent a 90-min dynamic baseline [

resultsSeven participants (4 females) completed the study. The mean peak BAL achieved was 61 ± 18 mg/dL. Acute alcohol significantly decreased [

conclusionsThis proof-of-concept study demonstrates that [

Indexed as

Alcohol DrinkingBrainCentral Nervous System DepressantsEthanolPositron-Emission TomographyReceptor, Metabotropic Glutamate 5AdultCarbon RadioisotopesFemaleHumansMaleOximesPyridinesRadiopharmaceuticals3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloximeCarbon RadioisotopesCentral Nervous System DepressantsEthanolGRM5 protein, humanOximesPyridinesRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5alcohol challengeglutamate releasemetabotropic glutamate type 5 receptorspositron emission tomographysocial drinkers

Identifiers

PMID40309934
PMCPMC12044519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.