Evidence map›Paper›PMID 40309713›Full record

ArticleJTCVS open2025

Sex differences in patterns of cardiovascular referral in patients with Marfan, Ehlers-Danlos, and Loeys-Dietz syndromes.

Christina Waldron, Afsheen Nasir, Kristina Wang, Alan Chou, Ely Erez, Prashanth Vallabhajosyula, Roland Assi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Hypertension drives thoracic aortic aneurysm and dissection in male, but not female, Marfan mice.Journal of the mechanical behavior of biomedical materials · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christina WaldronDivision of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Afsheen NasirDivision of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Kristina WangDivision of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Alan ChouDivision of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Ely ErezDivision of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Prashanth VallabhajosyulaDivision of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Roland AssiDivision of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.

Funding

Short-Term Reserch Training: Students in Health SchoolsT35HL007649 · NHLBI · YALE UNIVERSITY · PI Sarwat I Chaudhry, Erica L Herzog · 1987 to 2026
$5.7M
NHLBI NIH HHS T35 HL007649
6 · The paper itself

Abstract

Background: Diagnosis of Marfan (MFS), Ehlers-Danlos (EDS), and Loeys-Dietz (LDS) syndromes often warrants specialized evaluation for screening and surveillance of aortic disease. This study aims to characterize the rate of referral to cardiovascular medicine and cardiothoracic surgery in male and female patients diagnosed with MFS, EDS, or LDS. Methods: We conducted a retrospective review of patients with genetic or clinical diagnoses of MFS, EDS, or LDS from electronic medical records in a large healthcare system between 2013 and 2022. We explored the referral pattern to cardiovascular medicine and cardiothoracic surgery based on connective tissue disease and sex. Results: A total of 995 patients were identified (74% female), including 242 with MFS (41% female), 772 with EDS (87% female), and 31 with LDS (48% female). Referral rates to cardiovascular medicine and cardiothoracic surgery were 69% and 14%, respectively, with significantly higher rates for male patients compared to female patients (77% vs 66% [ Conclusions: Patients with MFS and LDS had high referral rates to cardiovascular medicine. Female patients with connective tissue diseases are less likely than male patients to be referred to cardiovascular medicine, particularly those with aortic pathologies.

Indexed as

aortic aneurysmaortic dissectionconnective tissue diseaseEhlers-Danlos syndromeLoeys-Dietz syndromeMarfan syndromesex differences

Identifiers

PMID40309713
PMCPMC12039419

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.