Evidence map›Paper›PMID 40309694›Full record

ArticleJTCVS open2025

Application of a degradable thin film to modulate perfusion to post-autotransplantation airways in rats.

Aravind Krishnan, Mahdi Forouharshad, Elbert Heng, Alyssa Garrison, Daniel Alnasir, Shubham Patil, Arman Farazdaghi, Moeed Fawad, Stefan Elde, Brandon A Guenthart and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aravind KrishnanDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Mahdi ForouharshadCenter for Nanomedicine at the Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Md.
Elbert HengDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Alyssa GarrisonDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Daniel AlnasirDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Shubham PatilDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Md.
Arman FarazdaghiDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Md.
Moeed FawadDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Stefan EldeDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Brandon A GuenthartDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Laura M EnsignCenter for Nanomedicine at the Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Md.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.
Kunal S ParikhCenter for Nanomedicine at the Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Md.
John W MacArthurDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Recipients of lung transplants experience the lowest long-term survival among all solid-organ transplant recipients. Airway complications contribute significantly to morbidity and mortality post-lung transplant and may be driven by airway devascularization inherent to procurement and implantation of the lungs. We studied application of biodegradable, nanofiber-based thin films to devascularized autotransplanted airways to mitigate airway ischemia. Methods: We used a rat tracheal autotransplantation model that replicates airway ischemia. Rats were divided into an operated control group (n = 18) and a treatment group (n = 12) receiving an electrospun film composed of randomly aligned polydioxanone (PDO) nanofibers applied to the circumferential surface of the transplanted trachea. Airway perfusion was assessed via laser speckle contrast analysis at 0, 3, and 10 days. Differences in perfusion units were calculated between the nontransplanted and transplanted segments of the trachea. Multimodal analysis of angiogenesis in tracheal autografts included immunoassay profiling for proangiogenic cytokines, histologic injury grading, and speckle angiography. Results: Qualitative and quantitative perfusion differences were demonstrated at days 0, 3, and 10. Nanofiber-based, PDO thin films significantly improved perfusion in the transplanted segment of trachea ( Conclusions: Application of a nanofiber-based, PDO thin film induced a local tissue response that improved perfusion and histologic injury scoring of the transplanted airway in an autotransplant model of airway devascularization. Immune multiplexing suggests local inflammatory responses may drive angiogenesis.

Indexed as

airway ischemiaangiogenesislung transplant

Identifiers

PMID40309694
PMCPMC12039443

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.