Evidence map›Paper›PMID 40309689›Full record

ArticleJTCVS open2025

Preoperative stroke predicts new postoperative clinically significant stroke in patients undergoing surgery for left-sided infective endocarditis.

Nithya D Rajeev, Markian M Bojko, Jessica S Clothier, Kamso Okonkwo, Kayvan Kazerouni, Serge Kobsa

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Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Nithya D RajeevDivision of Cardiac Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
Markian M BojkoDivision of Cardiac Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
Jessica S ClothierDivision of Cardiac Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
Kamso OkonkwoDivision of Cardiac Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
Kayvan KazerouniDivision of Cardiac Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
Serge KobsaDivision of Cardiac Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Operative timing remains controversial for patients with left-sided infective endocarditis (LSIE) with preoperative stroke (PREOS). Operative guidelines are determined on the basis of postoperative radiologically confirmed strokes (RCS). We evaluated the impact of PREOS on surgical outcomes. Methods: Over 15 years, 331 patients underwent valvular surgery for LSIE at our center. PREOS (n = 71, 21%) and non-PREOS (n = 260, 79%) cohorts were identified. Propensity score matching was performed. Logistic regression identified risk factors for postoperative clinical stroke (PCS, defined as any new postoperative neurologic deficit), RCS and mortality. Results: Among patients with PREOS, 24 of 71 (34%) had a hemorrhagic component, 34 of 71 (48%) were within 2 weeks of surgery, 46 of 71 (65%) experienced residual deficits, and 2 of 71 (3%) experienced hemorrhagic conversion postoperatively. Operative mortality was 24 of 331 (7%) and did not significantly differ between groups ( Conclusions: Among patients with LSIE undergoing surgery, PREOS is a risk factor for PCS and new renal failure. Patients with PREOS may require greater level of care upon discharge and may benefit from more stringent preoperative evaluation.

Indexed as

infective endocarditisneurologic deficitseptic embolistrokevalve repairvalve replacement

Identifiers

PMID40309689
PMCPMC12039449

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.