ArticleHealth science reports2025
Effect of Vitamin D3 on the Levels of Oxidative Stress and Expression of the NLRP3 Inflammatory Gene in Type 2 Diabetes Mellitus: A Randomized Clinical Trial.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Article
- Novel AI-Driven Precision Strategies in Diabetic Wound Healing: Immunomodulation and Advances in Smart Composite Nanocarriers.Pharmaceutics · 2026Review
- Beyond VDR: Vitamin D Metabolism Genes in Tuberculosis Susceptibility, Immune Response and Implications for Diabetes Mellitus.Infection and drug resistance · 2026Review
- Vitamin D alleviates type 2 diabetes by promoting autophagy and inhibiting inflammation via the NLRP3 inflammasome pathway.Open life sciences · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and chronic inflammation. The activation of the NLRP3 inflammasome is a key contributor to the inflammatory processes associated with T2DM, which can exacerbate disease progression. This study aims to evaluate the effects of vitamin D3 supplementation on oxidative stress markers and NLRP3 gene expression in patients with T2DM. Methods: Sixty-eight patients with T2DM, exhibiting HbA1c levels greater than 6.5% and serum 25(OH) vitamin D3 levels below 30 ng/mL, were enrolled in this randomized controlled trial. Participants were assigned to either a vitamin D3 group ( Results: The vitamin D3 group demonstrated a significant increase in serum 25(OH) vitamin D3 levels compared to the placebo group ( Conclusion: These findings suggest that vitamin D3 supplementation may effectively reduce inflammation in T2DM patients by lowering NLRP3 expression. This supports the potential role of vitamin D3 as an adjunctive therapy for managing inflammation and oxidative stress in individuals with T2DM.
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Registered trials
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