ReviewHealth science reports2025
The Role of Gabapentin in Enhanced Recovery After Surgery (ERAS) for Patients Undergoing Abdominal Procedures, A Systematic Review and Meta-Analysis.
Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Development of a machine learning-based nomogram for predicting chronic postsurgical pain after uniportal video-assisted thoracoscopic surgery.Journal of thoracic disease · 2025Article
- Role of Sarcopenia in Predicting 1-Year Outcomes After Mini-invasive Surgical or Endovascular Repair of Infrarenal Abdominal Aortic Aneurysms.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Postoperative pain management remains a significant challenge for patients undergoing abdominal surgery, with poorly managed pain adversely affecting recovery, leading to increased opioid use and associated side effects. Gabapentin, an anticonvulsant, has been proposed as an effective analgesic within enhanced recovery after surgery (ERAS) protocols to minimize opioid consumption and reduce postoperative nausea and vomiting (PONV). However, its role in perioperative pain management lacks consensus, necessitating a systematic review and meta-analysis. Methods: A systematic review and meta-analysis of randomized controlled trials and observational studies were conducted, following PRISMA guidelines. Databases including PubMed, Scopus, and EMBASE were searched up to August 2024 using terms such as "gabapentin," "postoperative pain," and "ERAS." Studies involving gabapentin or pregabalin in abdominal surgery were included. Pain was assessed using the visual analog scale (VAS), opioid consumption was converted to morphine equivalents, and PONV rates were analyzed. Meta-analysis was performed using STATA 17 software with a random-effects model due to high clinical heterogeneity. Results: Twenty-two studies with 1812 patients (909 in the gabapentin group and 903 in the control group) were included. Gabapentin significantly reduced postoperative pain (Hedges's g = -1.65, 95% CI: -2.34 to -0.97, Conclusion: Gabapentin demonstrates efficacy in reducing postoperative pain, opioid consumption, and PONV in patients undergoing abdominal surgery. Despite substantial heterogeneity across studies, the results suggest gabapentin as a valuable addition to ERAS protocols. Further research is necessary to optimize dosing strategies and address safety concerns, especially regarding sedation in vulnerable populations.
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Registered trials
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