ArticleFrontiers in toxicology2025
Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (
Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparative effects of dietary inorganic and nano forms of selenium on growth, hematological, biochemical, and antioxidant responses in Nile tilapia (Oreochromis niloticus).Tropical animal health and production · 2026Article
- A multi-omics systems toxicology framework reveals amino acid-mediated stress adaptation to deltamethrin exposure in a yeast model.Scientific reports · 2026Article
- De novo Genome Assembly, Annotation, and Comparative Analysis of the Lined Sole Achirus lineatus as a Resource for Evolutionary and Environmental Genomics.Marine biotechnology (New York, N.Y.) · 2026Article
- Integrated Transcriptomic and Metabolomic Analyses Reveal Physiological and Hepatic Metabolic Responses of Largemouth Bass (International journal of molecular sciences · 2025Article
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15 authors.
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Abstract
Introduction: Deltamethrin is a pyrethroid insecticide commonly used to kill animal parasites in aquaculture. However, increasing evidence suggests that deltamethrin affects the health of aquatic animals by causing tissue damage and even death. Methods: In this study, the damage caused by deltamethrin to the gill and liver tissues, as well as its effects on oxidative stress and immune metabolism, were studied in Results: We observed a positive correlation between the residual levels of deltamethrin (Del) and the exposure concentrations, with the highest residue detected in the 0.28 μg/L concentration group (0.0684 mg/kg at 7 days). Then, we observed different degrees of damage to the gill and liver tissues of the Paralichthys olivaceus, including swelling, apical fusion, shedding of gill secondary lamellae, liver cell necrosis, and nuclear vacuolization, by observing tissue sections. Lysozyme enzyme activity increased, whereas catalase and alkaline phosphatase enzyme activities decreased. The liver transcriptome results of the control and high-concentration (0.28 μg/L) groups showed that there were 697 differentially expressed genes, including 390 upregulated and 307 downregulated genes. These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways. Discussion: In summary, we found that deltamethrin induces oxidative stress and metabolic disorders in
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