Evidence map›Paper›PMID 40309445›Full record

SynthesisFrontiers in endocrinology2025

Recent advances and applications of optical coherence tomography angiography in diabetic retinopathy.

Qing Zhang, Di Gong, Manman Huang, Zhentao Zhu, Weihua Yang, Gaoen Ma

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Association of Remnant Cholesterol With the Retinal Capillary Plexus.Translational vision science & technology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Frontiers in ophthalmology · 2025
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qing Zhang *Department of Ophthalmology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang, Henan, China.
Di Gong *Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Manman HuangZhengzhou University People's Hospital, Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Zhentao ZhuDepartment of Ophthalmology, Huaian Hospital of Huaian City, Huaian, Jiangsu, China.
Weihua YangShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Gaoen MaDepartment of Ophthalmology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Optical coherence tomography angiography (OCTA), a noninvasive imaging technique, is increasingly used in managing ophthalmic diseases like diabetic retinopathy (DR). This review examines OCTA's imaging principles, its utility in detecting DR lesions, and its diagnostic advantages over fundus fluorescein angiography (FFA). Methods: We systematically analyzed 75 articles (2015-2024) from the Web of Science Core Collection, focusing on OCTA's technical principles, clinical applications in DR diagnosis, and its use in diabetes mellitus (DM) without DR and prediabetes. The use of artificial intelligence (AI) in OCTA image analysis for DR severity evaluation was investigated. Results: OCTA effectively identifies DR lesions and detects early vascular abnormalities in DM and prediabetes, surpassing FFA in noninvasiveness and resolution. AI integration enhances OCTA's capability to diagnose, evaluate, and predict DR progression. Discussion: OCTA offers significant clinical value in early DR detection and monitoring. Its synergy with AI holds promise for refining diagnostic precision and expanding predictive applications, positioning OCTA as a transformative tool in future ophthalmic practice.

Indexed as

Diabetic RetinopathyTomography, Optical CoherenceArtificial IntelligenceFluorescein AngiographyHumansartificial intelligencediabetic retinopathygradinglesion recognitionoptical coherence tomography angiography

Identifiers

PMID40309445
PMCPMC12040626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.