ArticleFrontiers in endocrinology2025
NSAID use may decrease serum Klotho levels.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To validate the hypothesis proposed by previous studies, which suggests that NSAID use may elevate Klotho levels. Method: We conducted a cross-sectional study involving 11,626 adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Multivariable linear regression and propensity score analysis were employed to evaluate the association between NSAID use and serum Klotho levels. Additionally, subgroup analyses were performed to assess the consistency of this relationship across various subgroups. Results: Multivariable linear regression analysis demonstrated that NSAID use was negatively correlated with serum Klotho levels (β = -25.48 [95% CI: -42.00, -8.96], p = 0.003). Additionally, sensitivity analysis results were consistent with the primary analysis. Subgroup analyses did not reveal any statistically significant interactions. Conclusion: Contrary to previous speculations, the use of NSAIDs is associated with a decrease in serum Klotho levels.
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