Evidence map›Paper›PMID 40309406›Full record

ArticleOpen forum infectious diseases2025

Serosurveillance to Support HPV Vaccination in England.

Kavita Panwar, Kazutomo Yokoya, Marta Checchi, Anja Anderson, Simon Tonge, Ray Borrow, Kate Soldan, Simon Beddows

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kavita PanwarVirus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, UK.
Kazutomo YokoyaVirus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, UK.
Marta ChecchiBlood Safety, Hepatitis, STI and HIV Division, UK Health Security Agency, London, UK.ORCID https://orcid.org/0000-0003-1398-9017
Anja AndersonBlood Safety, Hepatitis, STI and HIV Division, UK Health Security Agency, London, UK.ORCID https://orcid.org/0009-0007-1206-4190
Simon TongeSeroepidemiology Unit, UK Health Security Agency, Manchester, UK.
Ray BorrowSeroepidemiology Unit, UK Health Security Agency, Manchester, UK.
Kate SoldanBlood Safety, Hepatitis, STI and HIV Division, UK Health Security Agency, London, UK.
Simon BeddowsVirus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, UK.ORCID https://orcid.org/0000-0002-6879-6215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In 2020, the World Health Organization (WHO) declared a global strategy to accelerate the elimination of cervical cancer as a public health problem, for which high vaccination coverage rates are a key component. Since its inception in 2008, the UK national adolescent human papillomavirus (HPV) vaccination program has changed the vaccines being offered, the dosing regimen, and has become gender neutral. Methods: We conducted serosurveillance to evaluate the magnitude and durability of vaccine-induced humoral immunity across various schedule changes, including changing from the bivalent to the quadrivalent vaccine, changes from a 3-dose to 2-dose schedule and inclusion of boys. It does not yet cover more recent schedule changes that include the nonavalent vaccine. Serostatus and antibody levels (in IU/mL) are reported for all nonavalent vaccine types. Results: Our findings are consistent with data from clinical trials supporting durability of high vaccine-induced antibody levels through to adulthood (into the peak ages of exposure to sexually transmitted infections) and comparability between males and females. Conclusions: These data support the utility of serosurveillance to monitor population level immunity to inform and evaluate national HPV vaccination programs. This ongoing serosurveillance aims to identify any reductions in vaccine-induced immunity that could foretell of a potential weakening in HPV control.

Indexed as

antibodyhuman papillomavirusserosurveillancevaccine

Identifiers

PMID40309406
PMCPMC12039802

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.