Evidence map›Paper›PMID 40309345›Full record

ArticleNational science review2025

Piezoelectric dual-network tough hydrogel with on-demand thermal contraction and sonopiezoelectric effect for promoting infected-joint-skin-wound healing via FAK and AKT signaling pathways.

Jinlong Luo, Zhen Liang, Xin Zhao, Shengfei Huang, Yanan Gu, Zexing Deng, Jing Ye, Xingmei Cai, Yong Han, Baolin Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  19. Gold Nanoparticles for Wound Healing in Animal Models.Nanomaterials (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinlong LuoState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Zhen LiangDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Xin ZhaoState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Shengfei HuangState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Yanan GuDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zexing DengCollege of Materials Science and Engineering, Xi'an University of Science and Technology, Xi'an 710054, China.
Jing YeState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Xingmei CaiState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Yong HanState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Baolin GuoState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.ORCID https://orcid.org/0000-0001-6756-1441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dynamic and whole stage management of infected wound healing throughout the entire repair process, including intelligent on-demand wound closure and the regulation of the transition from bactericidal to reparative phases, remains a major challenge. This study develops sonopiezoelectric-effect-mediated on-demand reactive-oxygen-species release by incorporating piezoelectric barium titanate modified with gold nanoparticles and a thermally responsive dual-network tough hydrogel dressing with a physical network structure based on ureidopyrimidinone-modified gelatin crosslinked by multiple hydrogen bonds, and with a chemical network structure based on N-isopropylacrylamide and methacryloyl gelatin formed via radical polymerization. This hydrogel exhibits temperature-sensitive softening, on-demand thermal contraction performance, high mechanical strength, good tissue adhesion, outstanding piezoelectricity, tunable sonopiezoelectric behavior, regulatable photothermal properties and desirable biocompatibility. The tunable sonopiezoelectric effect enables the hydrogel to eliminate wound bacteria in the short term, and effectively promote human fibroblast proliferation and migration over the long term. The hydrogel dressing actively contracts to close wound edges and further promotes the healing of MRSA-infected skin defects in the neck of mice by promoting fibroblast migration, enhancing collagen deposition and facilitating angiogenesis via up-regulating the FAK and AKT signaling pathways, providing a novel design strategy for developing dressings targeting chronic joint-skin wounds.

Indexed as

chronic joint-skin wounddynamic wound managementon-demand thermal contractionpiezoelectricitysonopiezoelectric therapy

Identifiers

PMID40309345
PMCPMC12042750

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.