ArticleFrontiers in dementia2025
Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease.
Zachery D Morrissey, Pavan Kumar, Trongha X Phan, Mark Maienschein-Cline, Alex Leow, Orly Lazarov
Abstract read
In one paragraphArticle in Frontiers in dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
6 authors.
Zachery D MorrisseyGraduate Program in Neuroscience, University of Illinois Chicago, Chicago, IL, United States.
Pavan KumarDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL, United States.
Trongha X PhanDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL, United States.
Mark Maienschein-ClineResearch Informatics Core, University of Illinois Chicago, Chicago, IL, United States.
Alex LeowDepartment of Psychiatry, University of Illinois Chicago, Chicago, IL, United States.
Orly LazarovDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL, United States.
Funding
The role of PS1 in regulation of adult neurogenesis in the intact and Alzheimer?sR01AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2009 to 2026
$5.6MHippocampal neurogenesis in cognitive function and dysfunction in Alzheimer's disease.R01AG076940 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2022 to 2026
$3.7MNovel Therapeutic Approaches for NPC DiseaseR01NS124784 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Vinay Aakalu, Stephanie M Cologna · 2022 to 2026
$2.9MPlasticity circuits in Alzheimer s diseaseRF1AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2020 to 2021
$2.9MMechanisms underlying sporadic Alzheimer's diseaseR01AG060238 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2018 to 2022
$2.4MTraining program in the biology and translational research on Alzheimer's diseaseand related dementiasT32AG057468 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Stephanie M Cologna, Orly Lazarov · 2017 to 2026
$2.3MAcceleration of AD Phenotypes in Asymptomatic Mouse ModelsR01AG062251 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2018 to 2022
$2.2MThe role of APP in neurogenesis and AD in Down syndromeRF1AG079002 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2022 to 2022
$2.0MDevelopment of autophagy modulators for evaluation as a therapeutic strategy for Niemann-Pick Type CR01NS114413 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2020 to 2024
$2.0MConnecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regressionRF1MH125928 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEOW, ALEX, WU, YICHAO · 2021 to 2021
$1.3MSignaling pathways regulating hippocampal neurogenesis in the adult mouseR21AG061628 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2019 to 2020
$440kConnecting Neuronal Hyperexcitability and Sex Differences in Alzheimer's Disease (AD) using biophysically-informed in-silico brain simulations and experimental data from mouse models of ADR21AG087888 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY, LEOW, ALEX · 2024 to 2025
$435kNIA NIH HHS R01 AG033570NIA NIH HHS R01 AG060238NIA NIH HHS R01 AG062251NIA NIH HHS R01 AG076940NIA NIH HHS R21 AG061628NIA NIH HHS R21 AG087888NIA NIH HHS RF1 AG033570NIA NIH HHS RF1 AG079002NIA NIH HHS T32 AG057468NIMH NIH HHS RF1 MH125928NINDS NIH HHS R01 NS114413NINDS NIH HHS R01 NS124784
6 · The paper itselfAbstract
The mechanism by which neurogenesis regulates the profile of neurons and glia in the hippocampal formation is not known. Further, the effect of neurogenesis on neuronal vulnerability characterizing the entorhinal cortex in Alzheimer's disease (AD) is unknown. Here, we used
Indexed as
adult hippocampal neurogenesisAlzheimer's diseasehippocampusneurogenesisspatial transcriptomics
Identifiers
PMID40309339
PMCPMC12041076
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