ArticleJournal of inflammation research2025
The Association of Systemic Immune Inflammation Index (SII) and Platelet-to-Lymphocyte Ratio (PLR) on Coagulopathy and Prognosis in Patients with Traumatic Brain Injury.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Correlation of Routine Admission Inflammatory Biomarkers with Individual Traumatic Brain Lesion Types in Mild Traumatic Brain Injury.Biomedicines · 2026Article
- Hematological Biomarkers of the Obstructive Sleep Apnea Syndrome: A Machine Learning-Based Diagnostic and Prognostic Model.Journal of clinical medicine · 2025Article
- Early 24-Hour Changes in Systemic Immune-Inflammation Index Predict Acute Kidney Injury and Mortality in ICU Patients.Emergency medicine international · 2025Article
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12 authors.
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Abstract
Objective: We aimed to investigate the associations between inflammatory immune indicators, specifically systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and the coagulopathy and prognosis of traumatic brain injury (TBI) patients in ICU. Methods: One hundred sixty-one TBI patients were grouped into four groups. The outcomes included TBI-related coagulopathy and prognosis at six months after discharge. The association between SII, PLR and coagulopathy, and prognosis in TBI patients was elucidated by applying trend analysis, sensibility analysis, spearman correlation, restricted cubic splines and so on. Results: Sixty-four (39.75%) of 161 TBI patients were diagnosed with coagulopathy. In the unadjusted model, TBI patients in the lowest quarter of SII (≤966.60) and PLR levels (≤97.99) had a higher risk of coagulopathy than those in the highest quarter of SII (≥3096.16) [OR 0.169 (95% CI 0.052-0.547)] and PLR (≥255.39) [OR 0.098 (95% CI 0.028-0.340)]. After adjusting for covariates, the significant negative associations of results remained consistent in the sensitivity analyses. Restricted cubic splines revealed that an almost linear relationship between SII, PLR and coagulopathy risk and poor prognosis ( Conclusion: This study demonstrated that the SII and PLR had a significant correlation with coagulopathy risk and prognosis at 6 months after discharge. SII and PLR were predictive of coagulopathy and poor prognosis, specifically PLR value. It suggests that the SII and PLR might be promising biomarkers for predicting TBI-related coagulopathy and prognosis. Trial Registration: The study was registered in the ethics committee of the Third Affiliated Hospital of Southern Medical University (2024-ER-005).
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