Evidence map›Paper›PMID 40309223›Full record

ArticleToxicology research2025

Chaperone mediated autophagy modulates microglia polarization and inflammation via LAMP2A in ischemia induced spinal cord injury.

Dan Fu, Ziyou Li, Huafeng Feng, Fangling Fan, Wang Zhang, Liang He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dan FuDepartment of Pediatrics, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510900, China.
Ziyou LiDepartment of Anesthesiology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510900, China.
Huafeng FengDepartment of Anesthesiology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510900, China.
Fangling FanDepartment of Anesthesiology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510900, China.
Wang ZhangDepartment of Anesthesiology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510900, China.
Liang HeDepartment of Anesthesiology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510900, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI)-induced ischemic delayed paralysis is one of the most serious side effects of aneurysms surgeries. Recent studies prove that the activation of autophagy, including macroautophagy and micro-autophagy pathways, occur during SCI-induced brain neuron damage. However, the role of chaperone mediated autophagy (CMA) during SCI remains to be unveiled. In the present work, rat model of delayed paralysis after aneurysms operation and adenovrius induced LAMP2A knockdown in microglia cells were applied in the present work to investigate the involvement of LAMP2A-mediated CMA in the aneurysm operation related SCI and delayed paralysis. The results showed that LAMP2A was upregulated in the SCI procedure, and contributed to neuron death and pro-inflammation perturbation via inducing iNOS

Indexed as

chaperone mediated autophagyischemic delayed paralysislysosome-associated membrane protein type 2Amicrogliaspinal cord injury

Identifiers

PMID40309223
PMCPMC12038812

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.