Evidence map›Paper›PMID 40309206›Full record

ArticleFrontiers in psychology2025

Motor and cognitive function after unipolar depressive episodes: a 6 years longitudinal observational study.

Stephanie Straub, Markus A Hobert, Kirsten Emmert, Clint Hansen, Morad Elshehabi, Ulrike Suenkel, Isabel Wurster, Benjamin Roeben, Milan Zimmermann, Andreas J Fallgatter and 2 more

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In one paragraph

Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephanie StraubDepartment of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Markus A HobertDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Kirsten EmmertDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Clint HansenDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Morad ElshehabiDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Ulrike SuenkelDepartment of Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Isabel WursterDepartment of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Benjamin RoebenDepartment of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Milan ZimmermannDepartment of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Andreas J FallgatterGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Daniela BergDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Walter MaetzlerDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Unipolar depression is a frequent psychiatric disorder and associated with cognitive and motor deficits. It is also a prodromal or risk marker for various neurodegenerative diseases. Little research has been done on the extent to which motor and cognitive deficits persist in remitted depressive episode, and to what extent these deficits can be progressive. Methods: A total of 401 healthy subjects of the Tübingen TREND study aged between 50 and 80 years were examined over 6 years at intervals of 2 years. Of those, 81 had a positive history of unipolar depression (Dep+) and 320 had not (Dep-). We ruled out currently depressive participants. Mini-Mental-State Examination (MMSE), Consortium to Establish a Registry for Alzheimer's disease (CERAD), the motor part of the Movement disorder society-revised version of the Unified Parkinson disease rating scale (MDS-UPDRS III), gait speed, and dual tasking parameters were compared between groups. Results: Dep+ had lower gait velocity than Dep-. No significant change in parameters was found over the observed time. Discussion: Reduced gait speed in Dep+ may have potential as a diagnostic and prognostic marker for Dep- if confirmed in further studies. The lack of progression of all studied parameters over 6 years specifically in Dep+ argues against a relevant potential of this approach to define prodromal neurodegenerative cohorts by history of depression.

Indexed as

cognitionfunctional declinegait speedneurodegenerative disordersunipolar depression

Identifiers

PMID40309206
PMCPMC12041021

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.