ArticleFrontiers in pediatrics2025
Clinical efficacy and effect on neurotransmitter levels of Shaoma Zhijing granules in children with tic disorders.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Complementary and Integrative Medicine for the Treatment of Tourette's Syndrome.Movement disorders clinical practice · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the clinical efficacy of Shaoma Zhijing Granules in treating pediatric tic disorders and its impact on plasma neurotransmitter levels. Methods: Eighty pediatric patients with tic disorders were randomly divided into the Shaoma Zhijing group (40 cases) and the Tiapride group (40 cases). The Yale Global Tic Severity Scale (YGTSS) scores, clinical efficacy, and traditional Chinese medicine (TCM) syndrome evaluations were compared at baseline, 4 weeks, and 8 weeks after treatment. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to analyze the changes in plasma neurotransmitter levels before and after treatment. Results: Compared with baseline, both groups showed a decrease in YGTSS scores and TCM syndrome scores at 4 weeks and 8 weeks after treatment ( Conclusion: Shaoma Zhijing Granules demonstrate significant clinical efficacy and good safety in treating pediatric tic disorders. They effectively improve symptoms, thereby contributing to the enrichment of the TCM diagnostic and treatment system for pediatric tic disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.