Evidence map›Paper›PMID 40309162›Full record

ReviewNeurotrauma reports2025

Crossing the Valley of Death in Spinal Cord Injury: Learning from Successful Translators.

Vieri Failli, Stephen M Strittmatter, Martin E Schwab, Aileen J Anderson, Angela Ruban, Hassan Al-Ali, Armin Curt, Adrien Cohen, Jane T C Hsieh

Abstract readReview
In one paragraph

Review in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vieri FailliWings for Life, Salzburg, Austria.
Stephen M StrittmatterCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-8188-3092
Martin E SchwabInstitute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland.
Aileen J AndersonSue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, USA.
Angela RubanSackler Faculty of Medicine, Medicine and Health Sciences, Sagol School of Neuroscience, Tel Aviv University, Tel-Aviv, Israel.
Hassan Al-AliThe Miami Project to Cure Paralysis, Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Peggy and Harold Katz Drug Discovery Center, Katz Family Division of Nephrology and Hypertension, Department of Medicine, and Frost Institute for Data Science and Computing, University of Miami Miller School of Medicine, Miami, Florida, USA.
Armin CurtSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Adrien CohenSCI Ventures, London, United Kingdom.
Jane T C HsiehWings for Life, Salzburg, Austria.

Funding

Genome-Wide Discovery and Translational Research for Neural RepairR35NS097283 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2017 to 2024
$8.1M
NINDS NIH HHS R35 NS097283
6 · The paper itself

Abstract

A straightforward path to successful scientific translation remains uncharted, particularly in a complex progressive condition such as spinal cord injury (SCI), which affects multiple body functions simultaneously. Evolving regulatory requirements add to the complexity and expense of attaining a treatment that is both safe and efficacious. Although rare, there are examples of SCI scientists who have successfully navigated the "valley of death" from discovery science to completed clinical trials. This article reflects the translational journey of five SCI scientists who have encountered similar and different scenarios while striving to launch or complete a clinical trial. Learning from these experiences has identified lessons learned and gaps, particularly with respect to funding and support for SCI translation.

Indexed as

collaborative fundingspinal cord injurytranslational sciencetranslation medicineventure philanthropy

Identifiers

PMID40309162
PMCPMC12040567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.