Evidence map›Paper›PMID 40309115›Full record

ArticleFrontiers in microbiology2025

Influence of gut microbiota and immune markers in different stages of colorectal adenomas.

Xianmei Wang, Hang Chen, Meng Yang, Minshan Huang, Dan Zhang, Mingke Li, Hui Wang, Qingqing Zhou, Lihong Lu, Yu Li and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xianmei Wang *Yunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Hang Chen *Yunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Meng YangYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Minshan HuangYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Dan ZhangYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Mingke LiYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Hui WangYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Qingqing ZhouYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Lihong LuYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yu LiYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jiangkun YuState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, Yunnan, China.
Lanqing MaYunnan Institute of Digestive Disease, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Colorectal adenomas (CRA) are the primary precancerous lesions leading to colorectal cancer (CRC). Early detection and intervention of CRA can significantly reduce the incidence of CRC. We investigated the relationships between the gut microbiome and the expression levels of PD-L1, IL-6, and IFN-γ at different CRA stages. Methods: Participants were divided into normal, non-advanced adenoma (NAA), and advanced adenoma (AA) groups. PD-L1 expression in collected tissues was analyzed via immunohistochemistry (IHC) and Western blotting. Serum IL-6 and IFN-γ levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). 16S rRNA gene sequencing was used to examine gut microbiota changes, with correlation analysis to assess microbial influences on CRA progression. Results: The main differences in bacterial composition among the three groups were found within the Firmicutes and Bacteroidetes phyla. In the normal vs. NAA comparison, Conclusion: This study highlights the dynamic alterations in gut microbiota composition and their potential influence on the regulation of inflammatory cytokines and PD-L1 expression during CRA progression. The enrichment of protective taxa, such as

Indexed as

colorectal adenomacolorectal cancerIFN-γIL-6microbiotaPD-L1

Identifiers

PMID40309115
PMCPMC12040870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.