Evidence map›Paper›PMID 40309065›Full record

ArticleRSC chemical biology2025

Synthesis of 4-azido sialic acid for testing against Siglec-7 and in metabolic oligosaccharide engineering.

Taylor E Gray, Kristin B Labasan, Gour C Daskhan, Duong T Bui, Maju Joe, Dhanraj Kumawat, Edward N Schmidt, John S Klassen, Matthew S Macauley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Taylor E GrayDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.ORCID https://orcid.org/0000-0002-0016-0405
Kristin B LabasanDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.ORCID https://orcid.org/0000-0002-8519-112X
Gour C DaskhanDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.
Duong T BuiDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.ORCID https://orcid.org/0000-0001-9274-0759
Maju JoeDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.ORCID https://orcid.org/0000-0003-0664-5275
Dhanraj KumawatDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.
Edward N SchmidtDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.
John S KlassenDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.
Matthew S MacauleyDepartment of Chemistry, University of Alberta Edmonton T6G 2G2 Canada.ORCID https://orcid.org/0000-0003-4579-1048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An important approach for tracking and visualizing sialic acid-containing glycans involves using sialic acid reporters functionalized with bioorthogonal handles. More specifically, metabolic oligosaccharide engineering (MOE) commonly employs monosaccharides with an alkyne or azide handle for incorporation into cellular glycans, followed by a subsequent click reaction to elaborate with a biotin or fluorophore handle. For sialic acid, this has been carried out extensively, with an azide or alkyne appended to the C5

Identifiers

PMID40309065
PMCPMC12038855

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.