ArticleTransplantation direct2025
Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults.
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107 authors.
Tobias LaueDepartment of Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0009-0003-3784-1444
Maria Pilar BallesterDepartment of Gastroenterology and Hepatology, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Lily MeoliInstitute of Liver Studies, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Carl GrabitzDepartment of Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Eva UsonEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Lorenzo D AntigaPediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.ORCID https://orcid.org/0000-0001-7150-3148
Valerie McLinGastroenterology, Hepatology and Pediatric Nutrition Unit, Department of pediatrics, Gynecology and Obstetrics, Swiss Pediatric Liver Center, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Montserrat PujadasEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Ângela Carvalho-GomesHepatology, HBP Surgery and Transplantation, Hepatology and Liver Transplant Unit, IIS La Fe University Hospital, Valencia, Spain.
Ivan SahucoHepatology, HBP Surgery and Transplantation, Hepatology and Liver Transplant Unit, IIS La Fe University Hospital, Valencia, Spain.
Ariadna BonoHepatology, HBP Surgery and Transplantation, Hepatology and Liver Transplant Unit, IIS La Fe University Hospital, Valencia, Spain.
Federico D'AmicoInfectious Diseases Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Raffaela ViganòHepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Elena DiagoDepartment of Gastroenterology and Hepatology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHIM, Madrid, Spain.
Beatriz Tormo LanserosDepartment of Gastroenterology and Hepatology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHIM, Madrid, Spain.
Elvira IngleseHepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Dani Martinez VazquezLiver Unit, Hospital Universitario Valle de Hebron, Barcelona, Spain.
Annelotte BroekhovenDepartment of Gastroenterology and Hepatology, Leiden University Medical Center Transplant Center, Leiden, The Netherlands.
Marjolein KikkertLaboratory of Molecular Virology, Leiden University Medical Center, Leiden University Center of Infectious Diseases (LUCID), Leiden, The Netherlands.
Shessy P Torres MoralesLaboratory of Molecular Virology, Leiden University Medical Center, Leiden University Center of Infectious Diseases (LUCID), Leiden, The Netherlands.
Sebenzile K MyeniLaboratory of Molecular Virology, Leiden University Medical Center, Leiden University Center of Infectious Diseases (LUCID), Leiden, The Netherlands.
Mar Riveiro-BarcielaCIBEREHD, Madrid, Spain.
Adriana PalomCIBEREHD, Madrid, Spain.
Nicola ZeniUnit of Internal Medicine and Hepatology (UIMH), Department of Medicine-DIMED, University of Padova, Padova, Italy.
Alessandra BroccaUnit of Internal Medicine and Hepatology (UIMH), Department of Medicine-DIMED, University of Padova, Padova, Italy.
Annarosa CussighHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University of Udine, Udine, Italy.
Sara CmetHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University of Udine, Udine, Italy.
Maria Desamparados Escudero-GarcíaDepartment of Gastroenterology and Hepatology, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Matteo StoccoDepartment of Gastroenterology and Hepatology, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Leonardo Antonio NatolaAzienda Ospedaiera Universitaria Integrata Verona, Verona, Italy.
Donatella IeluzziAzienda Ospedaiera Universitaria Integrata Verona, Verona, Italy.
Veronica PaonAzienda Ospedaiera Universitaria Integrata Verona, Verona, Italy.
Angelo SangiovanniDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Elisa FarinaDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Clara DibenedettoDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Yolanda Sánchez-TorrijosHospital Universitario Virgen del Rocio, Sevilla. Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Sevilla, Spain.
Ana Lucena-VarelaHospital Universitario Virgen del Rocio, Sevilla. Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Sevilla, Spain.
Eva RománCIBEREHD, Madrid, Spain.
Elisabet SánchezCIBEREHD, Madrid, Spain.
Rubén Sánchez-AldehueloServicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto Salud Carlos III, Madrid, Spain.
Julia López-CardonaServicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto Salud Carlos III, Madrid, Spain.
Dhaarica JeyanesanInstitute of Liver Studies, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Alejandro Esquivel MorochoInstitute of Liver Studies, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Itzel Canas-PerezRoyal Free London NHS Foundation Trust, London, United Kingdom.
Christine EastgateRoyal Free London NHS Foundation Trust, London, United Kingdom.
Simone Di ColaDepartment of Translational and Precision Medicine, University of Rome Sapienza, Rome, Italy.
Lucia LapennaDepartment of Translational and Precision Medicine, University of Rome Sapienza, Rome, Italy.
Giacomo ZaccheriniDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Deborah BongiovanniDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Antonio RivaRoger Williams Institute of Liver Studies, King's College London & Foundation for Liver Research, London, United Kingdom.
Rajni SharmaRoger Williams Institute of Liver Studies, King's College London & Foundation for Liver Research, London, United Kingdom.
Hio Lam Phoebe TsouRoger Williams Institute of Liver Studies, King's College London & Foundation for Liver Research, London, United Kingdom.
Nicola HarrisRoger Williams Institute of Liver Studies, King's College London & Foundation for Liver Research, London, United Kingdom.
Paola ZanagaDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Katia SayafDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Sabir HossainMid & South Essex NHS Foundation Trust, Basildon, United Kingdom.
Javier CrespoGastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Santander, Spain.
Mercedes Robles-DíazCIBEREHD, Madrid, Spain.
Antonio MadejónLiver Unit, Hospital Universitario La Paz, CIBERehd, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.
Helena DegrooteDepartment of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.
Marko KorenjakEuropean Liver Patients' Association.
Xavier VerhelstEuropean Reference Network (ERN)RARE-LIVER.
Javier García-SamaniegoLiver Unit, Hospital Universitario La Paz, CIBERehd, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.
Raúl J AndradeCIBEREHD, Madrid, Spain.
Paula IruzubietaGastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Santander, Spain.
Gavin WrightMid & South Essex NHS Foundation Trust, Basildon, United Kingdom.
Paolo CaraceniDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Manuela MerliDepartment of Translational and Precision Medicine, University of Rome Sapienza, Rome, Italy.
Vishal C PatelInstitute of Liver Studies, King's College Hospital NHS Foundation Trust, London, United Kingdom.ORCID https://orcid.org/0000-0001-6616-3628
Amir GanderRoyal Free London NHS Foundation Trust, London, United Kingdom.
Agustín AlbillosServicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto Salud Carlos III, Madrid, Spain.
Germán SorianoCIBEREHD, Madrid, Spain.
Maria Francesca DonatoDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
David SacerdotiAzienda Ospedaiera Universitaria Integrata Verona, Verona, Italy.
Pierluigi ToniuttoHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University of Udine, Udine, Italy.
Maria ButiCentral Unit of Clinical Research and Clinical Trials, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
Christophe DuvouxDepartment of Hepatology-Liver Transplant Unit, Henri Mondor Hospital-APHP, Paris Est University, Paris, France.
Paolo Antonio GrossiDepartment of Medicine and Surgery, University of Insubria, Infectious and Tropical Diseases Unit, ASST Sette Laghi, Varese, Italy.
Thomas BergEuropean Association for the Study of the Liver.
Wojciech G PolakDivision of HPB and Transplant Surgery, Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Massimo PuotiInfectious Diseases Niguarda Great Metropolitan Hospital, University of Milano Bicocca, Milan, Italy.
Anna Bosch-ComasEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Luca S BelliHepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Patrizia BurraDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Francesco Paolo RussoDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Minneke CoenraadDepartment of Gastroenterology and Hepatology, Leiden University Medical Center Transplant Center, Leiden, The Netherlands.
José Luis CallejaDepartment of Gastroenterology and Hepatology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHIM, Madrid, Spain.
Giovanni PerriconeHepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Shilpa ChokshiRoger Williams Institute of Liver Studies, King's College London & Foundation for Liver Research, London, United Kingdom.
Marina BerenguerHepatology, HBP Surgery and Transplantation, Hepatology and Liver Transplant Unit, IIS La Fe University Hospital, Valencia, Spain.
Joan ClàriaEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Richard MoreauEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Javier FernándezEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Vicente ArroyoEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Paolo AngeliEuropean Reference Network (ERN)RARE-LIVER.
Cristina Sánchez-GarridoEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Javier AmpueroHospital Universitario Virgen del Rocio, Sevilla. Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Sevilla, Spain.
Salvatore PianoEuropean Reference Network (ERN)RARE-LIVER.
Emanuele NicastroPediatric Hepatology, Gastroenterology and Transplantation, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Nathalie RockGastroenterology, Hepatology and Pediatric Nutrition Unit, Department of pediatrics, Gynecology and Obstetrics, Swiss Pediatric Liver Center, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Debbie ShawcrossSchool of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, Roger Williams Institute of Liver Studies, King's College London, London, United Kingdom.
Lindsey EdwardsCentre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom.
Frauke MutschlerDepartment of Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Anette MelkDepartment of Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Gautam MehtaRoyal Free London NHS Foundation Trust, London, United Kingdom.
Ulrich BaumannDepartment of Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Rajiv JalanEuropean Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR. Methods: A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA. Results: A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], Conclusions: Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.
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