Evidence map›Paper›PMID 40309009›Full record

ArticleFrontiers in molecular biosciences2025

Metabolomic analysis of fatal hypothermia using ultra-high-performance liquid chromatography‒mass spectrometry.

Jia-Hao Li, Jia-Li Liu, Jian-Wen Song, Wei-Liang Deng, Xin-Zhi Cao, Zhong-Wen Wu, Ding-Hao Chen, Hui Wang, Song Yu, Qi Wang

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Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia-Hao Li *Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Jia-Li Liu *Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Jian-Wen Song *Forensic Appraisal Department, Guangdong Provincial Forensic Science of Evidence Materials (Nantian) Engineering Technology Research Center, Shenzhen, Guangdong, China.
Wei-Liang DengGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Xin-Zhi CaoGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Zhong-Wen WuGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Ding-Hao ChenGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Hui WangDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, National Children's Medical Center for South Central Region, Guangzhou, Guangdong, China.
Song YuForensic Appraisal Department, Guangdong Provincial Forensic Science of Evidence Materials (Nantian) Engineering Technology Research Center, Shenzhen, Guangdong, China.
Qi WangGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The identification of fatal hypothermia remains a significant challenge in forensic medicine. Metabolomics, which reflects the overall changes in endogenous metabolites within an organism, holds substantial value in the exploration of disease mechanisms and the screening of molecular markers. Methods: Using ultra-high-performance liquid chromatography‒mass spectrometry (UHPLC‒MS), we conducted a metabolomic analysis of serum, heart, lung, and kidney tissues from mice with fatal hypothermia. Results: A total of 67 metabolites significantly differed across all the tissues, involving pathways such as the TCA cycle, fatty acid oxidation, arginine metabolism, histamine metabolism, and antioxidant-related pathways. Each tissue also displayed unique metabolic alterations. Additionally, we observed significant differences in the metabolomic profiles of kidney tissues from mice with different survival times. Conclusion: Our findings contribute to elucidate the underlying mechanisms involved and provide a foundation for the forensic identification of markers of fatal hypothermia.

Indexed as

fatal hypothermiaforensic medicineidentificationmetabolomicUHPLC-MS

Identifiers

PMID40309009
PMCPMC12040645

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