Evidence map›Paper›PMID 40308894›Full record

ArticleFrontiers in aging neuroscience2025

Effects of m

Huan Chen, Fangzhen Guo, Yan Zhao, Wei Liu, Bingyu Chen, Chang Wang, Lining Huang, Sufang Jiang, Xiaowei Ma, Huiling Ren and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. METTL3-mediated mTranslational psychiatry · 2026
    Article
  2. Nanopore-mFrontiers in genetics · 2026
    Article
  3. mEpigenomes · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Huan Chen *Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Fangzhen Guo *Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Yan ZhaoDepartment of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Wei LiuDepartment of Immunology, Hebei Medical University, Shijiazhuang, China.
Bingyu ChenDepartment of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Chang WangDepartment of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Lining HuangHebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, China.
Sufang JiangHebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, China.
Xiaowei MaDepartment of Neurology, First Hospital of Hebei Medical University, Shijiazhuang, China.
Huiling RenHebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, China.
Sha LiDepartment of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Huixian CuiDepartment of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alzheimer's disease (AD) is a common neurodegenerative disorder affecting older adults, characterized by progressive cognitive decline and pathological features such as amyloid plaque deposition, neuronal loss, and synaptic reduction. RNA N6-methyladenosine (m Methods: This study employed the overexpression of methyltransferase-like protein 16 (METTL16), or overexpression of methionine adenosyltransferase 2A (MAT2A), or a combination of METTL16 overexpression with MAT2A knockdown to explore the influence of METTL16 on the regulation of MAT2A in cognitive function, hippocampal synaptic plasticity, and amyloid-beta (Aβ Results: Our findings indicated a reduction in m Conclusion: The present study demonstrated that METTL16 enhances learning and memory in 5 × FAD mice by regulating MAT2A mRNA m

Indexed as

Alzheimer’s diseaselearning and memorym6A methylation modificationMAT2AMETTL16

Identifiers

PMID40308894
PMCPMC12040962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.