Evidence map›Paper›PMID 40308830›Full record

ArticleWorld journal of hepatology2025

Hepatitis E virus infection-triggered intrahepatic cholestasis: A case report.

Stephan Drexler, Frederic Haedge, Susanne N Weber, Marcin Krawczyk, Matthias S Matter, Carol I Geppert, Achim Weber, Bruno Stieger, Christian Trautwein, Andreas E Kremer

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Cholestasis in hepatitis E virus infection.World journal of hepatology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephan DrexlerDepartment of Medicine III, University Hospital Aachen, Aachen 52070, Germany. sdrexler@ukaachen.de.
Frederic HaedgeDepartment of Medicine III, University Hospital RWTH Aachen, Aachen 52070, Germany.
Susanne N WeberDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg 66424, Germany.
Marcin KrawczykDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg 66424, Germany.
Matthias S MatterInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel 4031, Switzerland.
Carol I GeppertDepartment of Pathology, Univ Erlangen Nurnberg, Erlangen D-91054, Germany.
Achim WeberInstitute of Molecular Cancer Research, University Hospital Zurich and University Zurich, Zurich 8091, Switzerland.
Bruno StiegerDepartment of Gastroenterology and Hepatology, University Hospital Zürich, University of Zürich, Zurich 8091, Switzerland.
Christian TrautweinDepartment of Internal Medicine III, University Hospital RWTH Aachen, Aachen 52070, Germany.
Andreas E KremerDepartment of Gastroenterology and Hepatology, University Hospital Zürich, University of Zürich, Zurich 8091, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic disorders affecting hepatobiliary transporters can be triggered by various factors, resulting in marked cholestasis. CASE SUMMARY: We report two patients who experienced a severe episode of intrahepatic cholestasis triggered by an acute hepatitis E virus infection. Following an extensive clinical examination that ruled out common causes of cholestatic liver damage, we conducted next-generation sequencing to determine the genetic profiles of the patients. The analysis revealed several known and unknown variants in genes associated with hepatobiliary transporters and bile salt regulation, including

conclusionOur findings introduce hepatitis E viral infection as a novel trigger for intrahepatic cholestasis, and we categorize the significance of the various genetic variants based on the current state of research.

Indexed as

ATP8B1Case reportHepatitis EIntrahepatic cholestasisNext generation sequencing

Identifiers

PMID40308830
PMCPMC12038418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.