ReviewFrontiers in pharmacology2025
Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Apoptosis and Cell Cycle Dysregulation in AmpligoJournal of xenobiotics · 2026Article
- Diquat-induced organ toxicity: a focus on regulated cell death pathways and mitochondrial dysfunction.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical overexposure is a significant concern in both environmental and occupational settings, often leading to oxidative stress and subsequent cellular damage. The review covers the oxidative stress induced by chemical overexposure to substances such as pesticides (including pyrethroid, deltamethrin, β-cyfluthrin, malathion, triflumuron, methomyl, diquat, cypermethrin, thiamethoxam, and profenofos), medications (acetaminophen), nanoparticles (including zinc oxide, iron, silver, and titanium dioxide), heavy metals (including cadmium, vanadium), and some organic chemicals (including diethylnitrosamine and benzo(a)pyrene). Focusing on preclinical evidence from animal models and cell-based studies, essential oils have been shown to significantly enhance antioxidative enzyme activities, including superoxide dismutase, catalase, and glutathione peroxidase, while also increasing levels of non-enzymatic antioxidants such as glutathione and uric acid. Additionally, essential oils contribute to the restoration of biochemical parameters, including creatinine, uric acid, and urea levels, while mitigating oxidative damage by reducing cell membrane injury, apoptosis, and histopathological alterations. Additionally, this review evaluates the protective benefits of essential oils against chemical overexposure in animal models. The underlying mechanism is involved in alleviating hepatorenal damage. This review underscores the considerable promise of essential oils as candidates for medicinal applications in functional foods or medicines, particularly in preventing oxidative stress induced by various chemical overexposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.