Evidence map›Paper›PMID 40308741›Full record

ArticleHealth and metabolism2025

Vascular and metabolic responses to elevated circulating PDGF-BB in mice: A multiparametric MRI study.

Xiuli Yang, Jiekang Wang, Yuguo Li, Mei Wan, Zhiliang Wei

Abstract read
In one paragraph

Article in Health and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Longitudinal MRI Characterization of TNMR in biomedicine · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiuli YangRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jiekang WangDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yuguo LiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mei WanDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zhiliang WeiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Identifying A Skeleton-Derived Factor for Vascular AgingR01AG072090 · NIA · JOHNS HOPKINS UNIVERSITY · PI WAN, MEI · 2021 to 2025
$2.4M
Pathophysiological mechanisms of hypoperfusion in mouse models of Alzheimer?s disease and small vessel diseaseR01AG081932 · NIA · JOHNS HOPKINS UNIVERSITY · PI Zhiliang Wei · 2023 to 2026
$2.1M
Characterization and validation of cerebrovascular reactivity (CVR) as a biomarker of vascular dementia in mouse modelsR21NS119960 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WEI, ZHILIANG · 2021 to 2021
$465k
NIA NIH HHS R01 AG072090NIA NIH HHS R01 AG081932NIBIB NIH HHS P41 EB031771NINDS NIH HHS R21 NS119960
6 · The paper itself

Abstract

Elevated circulating platelet-derived growth factor-BB (PDGF-BB) has been implicated in various aged-related pathologies and, therefore, is recognized as a potential pro-aging factor. Despite extensive studies on the pathological characterizations centering PDGF-BB/PDGFRβ signaling alterations, there is limited research on the neurofunctional responses to elevated circulating PDGF-BB, primarily because

Indexed as

cerebral blood flowcerebral metabolic rate of oxygendiffusionoxygen extraction fractionPDGF-BBrelaxation time

Identifiers

PMID40308741
PMCPMC12040407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.