Evidence map›Paper›PMID 40308693›Full record

ReviewFrontiers in veterinary science2025

Mechanisms by which phytogenic extracts enhance livestock reproductive health: current insights and future directions.

Adedeji O Adetunji, Jacqueline Price, Henrietta Owusu, Esiosa F Adewale, Precious Adedayo Adesina, Tolulope Peter Saliu, Zhendong Zhu, Christian Xedzro, Emmanuel Asiamah, Shahidul Islam

Erratum issuedAbstract readReview
In one paragraph

Review in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Effects of OralAnimals : an open access journal from MDPI · 2026
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  6. Effects ofVeterinary and animal science · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Adedeji O AdetunjiDepartment of Agriculture, University of Arkansas at Pine Bluff, Pine Bluff, AR, United States.
Jacqueline PriceDepartment of Agriculture, University of Arkansas at Pine Bluff, Pine Bluff, AR, United States.
Henrietta OwusuDepartment of Agriculture, University of Arkansas at Pine Bluff, Pine Bluff, AR, United States.
Esiosa F AdewaleDepartment of Biology, University of Louisville, Louisville, KY, United States.
Precious Adedayo AdesinaNational Center for Advancing Translational Sciences, Division for Pre-Clinical Innovation, National Institutes of Health, Bethesda, MD, United States.
Tolulope Peter SaliuDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, United States.
Zhendong ZhuCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Christian XedzroLaboratory of Food Microbiology and Hygiene, Hiroshima University, Higashihiroshima, Japan.
Emmanuel AsiamahDepartment of Agriculture, University of Arkansas at Pine Bluff, Pine Bluff, AR, United States.
Shahidul IslamDepartment of Agriculture, University of Arkansas at Pine Bluff, Pine Bluff, AR, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reproductive health is a critical determinant of livestock productivity and economic sustainability. However, it is often compromised by infectious diseases, environmental stressors, and nutritional deficits. Phytogenic extracts-bioactive compounds derived from medicinal plants-have emerged as sustainable alternatives to synthetic antibiotics and hormones, exhibiting antimicrobial, antioxidant, and immunomodulatory properties. These extracts influence key reproductive processes such as follicular development, oocyte maturation, and endometrial health while mitigating the detrimental effects of oxidative stress and pathogenic infections. Recent findings suggest that phytogenic extract can enhance reproductive performance, improve oocyte quality, and support pregnancy outcomes. Despite the growing body of evidence, optimal application strategies and the full breadth of their biological effects remain insufficiently explored. This review focuses on the molecular mechanisms modulated by phytogenic extracts, particularly in the context of hormone regulation, immune modulation, and oxidative stress mitigation. We also identify critical knowledge gaps and propose future research directions to optimize the use of phytogenic extracts as a sustainable approach to enhancing livestock reproductive health.

Indexed as

bioactive compoundshormone regulationimmune modulationlivestock reproductionoxidative stress mitigationphytogenic extractsplant extractreproductive health

Identifiers

PMID40308693
PMCPMC12042781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.