Evidence map›Paper›PMID 40308628›Full record

ArticleClinical and translational radiation oncology2025

Rectal stenosis after immunotherapy in a mismatch repair deficient rectal cancer. Case report and review of literature.

Marcel Büttner, Ulrike Schempf, Robert Bachmann, Rüdiger Hoffmann, Christopher Schroeder, Sven Mattern, Stephan Singer, Marc Steinle, Maximilian Niyazi, Michael Bitzer and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marcel BüttnerDepartment of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.
Ulrike SchempfDepartment of Internal Medicine I, University Hospital Tuebingen 72076 Tuebingen, Germany.
Robert BachmannGeneral, Visceral and Transplantation Surgery, Eberhard-Karl-Universität, University Hospital Tübingen, 72076 Tuebingen, Germany.
Rüdiger HoffmannDepartment of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany.
Christopher SchroederInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Sven MatternDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany.
Stephan SingerDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany.
Marc SteinleDepartment of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.
Maximilian NiyaziDepartment of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.
Michael BitzerDepartment of Internal Medicine I, University Hospital Tuebingen 72076 Tuebingen, Germany.
Cihan GaniDepartment of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a 57-year-old male patient who presented with a circumferential cT3 cN1 rectal adenocarcinoma in the mid rectum. The tumor was found to be mismatch repair deficient/microsatellite instable (dMMR/MSI). Instead of multimodality treatment with chemoradiotherapy immunotherapy with Dostarlimab was initiated. Treatment was well-tolerated in general and endoscopy and MRI showed early signs of treatment response. Despite this, the patient developed intestinal obstruction due to scarring that required repeat balloon dilations. In contrast to other oncological treatments, obstructions may worsen during immunotherapy in dMMR rectal cancers. This information has to be considered when patients are consulted regarding the optimal treatment after disease.

Indexed as

Colorectal cancerImmunotherapyRectal cancerStenosis

Identifiers

PMID40308628
PMCPMC12041760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.