Evidence map›Paper›PMID 40308422›Full record

ReviewCureus2025

Balancing Between Negative Appendectomy and Complicated Appendicitis: A Persisting Reality Under the Rule of the Uncertainty Principle.

Stylianos Roupakias, Katerina Kambouri, Angelos Al Nimer, Konstantina Bekiaridou, Evangelos Blevrakis, Christos Tsalikidis, Xenophon Sinopidis

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stylianos RoupakiasSchool of Medicine, University of Patras, Patras, GRC.
Katerina KambouriPediatric Surgery, University Hospital of Alexandroupolis, Alexandroupolis, GRC.
Angelos Al NimerSurgery, University of Gothenburg, Gothenburg, SWE.
Konstantina BekiaridouPediatric Surgery, University Hospital of Alexandroupolis, Alexandroupolis, GRC.
Evangelos BlevrakisPediatric Surgery, University of Crete, Heraklion, GRC.
Christos TsalikidisGeneral Surgery, University Hospital of Alexandroupolis, Alexandroupolis, GRC.
Xenophon SinopidisSchool of Medicine, University of Patras, Patras, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uncertainty is inherent in medical practice. False-negative decisions can delay treatments and result in adverse outcomes in children with acute appendicitis (AA). On the other hand, false-positive surgery decisions lead to unnecessary appendectomies. Impressive technological advancements, such as magnetic resonance imaging and laparoscopy, have reduced but failed to eliminate the occurrence of erroneous decisions. Furthermore, there seems to be a fundamental limit to further reduction, especially in eliminating the rates of negative appendectomy or, oppositely, complicated appendicitis. What does this mean for the pediatric surgeon? Will we ever be able to eliminate our mistakes? This systematic review emphasizes the importance of understanding the potential abilities and limitations of different diagnostic options, as well as the impact of decisions in the face of uncertainty.

Indexed as

childrencomplicated appendicitisdiagnostic methodsdiagnostic uncertaintynegative appendectomy

Identifiers

PMID40308422
PMCPMC12042725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.