Evidence map›Paper›PMID 40308409›Full record

ArticleCureus2025

Assessing the Effectiveness of Antibiotic Irrigation to Reduce Bacterial Load at the Spinal Surgical Site: An In-Vitro Study.

Rawan Masarwa, Ofir Uri, Abed Athamna, Sarit Freimann, Ali Yassin, Elie Najjar, Rodrigo Muscogliati, Weronika Nocun, Eyal Behrbalk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rawan MasarwaCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Ofir UriCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Abed AthamnaCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Sarit FreimannCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Ali YassinCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Elie NajjarCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Rodrigo MuscogliatiSchool of Medicine, Hull York Medical School, York, GBR.
Weronika NocunCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Eyal BehrbalkCentre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Intra-operative surgical site irrigation with antibiotics is believed to reduce the risk of infection in spine surgeries involving instrumentation. However, despite its frequent use, there is limited supporting evidence for this practice. This prospective in-vitro study aims to evaluate the effect of short-term antibiotic exposure on the growth of common pathogens associated with wound infections. Furthermore, this study aims to determine the optimal duration of antibiotic exposure to eradicate common surgical site infection organisms. Methods A suspension of one of three micro-organisms: (1)

Indexed as

intra-operative antibiotic prophylaxisin-vitro studypost-operative wound infectionsspine surgerysurgical site infectionsurgical site irrigation

Identifiers

PMID40308409
PMCPMC12043249

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.