Evidence map›Paper›PMID 40308211›Full record

ArticleNucleic acids research2025

Cytoscape Web: bringing network biology to the browser.

Keiichiro Ono, Dylan Fong, Chengzhan Gao, Christopher Churas, Rudolf Pillich, Joanna Lenkiewicz, Dexter Pratt, Alexander R Pico, Kristina Hanspers, Yihang Xin and 7 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Keiichiro OnoDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Dylan FongDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Chengzhan GaoDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Christopher ChurasDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Rudolf PillichDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Joanna LenkiewiczDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Dexter PrattDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Alexander R PicoData Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158, United States.
Kristina HanspersData Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158, United States.ORCID 0000-0001-5410-599X
Yihang XinData Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158, United States.
John MorrisResource for Biocomputing, Visualization and Informatics, University of California, San Francisco, CA 94118, United States.ORCID 0000-0003-0290-7979
Mike KuceraThe Donnelly Centre, University of Toronto, Ontario M5S 3E1, Canada.
Max FranzThe Donnelly Centre, University of Toronto, Ontario M5S 3E1, Canada.
Christian LopesThe Donnelly Centre, University of Toronto, Ontario M5S 3E1, Canada.
Gary BaderThe Donnelly Centre, University of Toronto, Ontario M5S 3E1, Canada.ORCID 0000-0003-0185-8861
Trey IdekerDepartment of Medicine, University of California, San Diego, CA 92093, United States.
Jing ChenDepartment of Medicine, University of California, San Diego, CA 92093, United States.ORCID 0000-0002-9291-7507

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
CYTOSCAPE: AN ECOSYSTEM FOR NETWORK GENOMICSU24HG012107 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jing Chen, PIETER C DORRESTEIN · 2022 to 2026
$6.5M
The Network Data Exchange - a Network Commons for BiologistsU24CA269436 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Dexter Pratt · 2023 to 2026
$3.5M
NCI NIH HHS U24 CA269436NCI NIH HHS U24CA269436NHGRI NIH HHS U24 HG012107NHGRI NIH HHS U24HG012107NIGMS NIH HHS P41 GM103504NIGMS NIH HHS P41GM103504NIH HHS
6 · The paper itself

Abstract

Since its introduction in 2003, Cytoscape has been a de facto standard for visualizing and analyzing biological networks. We now introduce Cytoscape Web (https://web.cytoscape.org), an online implementation that captures the interface and key visualization functionality of the desktop while providing integration with web tools and databases. Cytoscape Web enhances accessibility, simplifying collaboration through online data sharing. It integrates with Cytoscape desktop via the CX2 network exchange format and with the Network Data Exchange for storing and sharing networks. The platform supports extensibility through an App framework for UI components and Service Apps for algorithm integration, fostering community-driven development of new analysis tools. Overall, Cytoscape Web enhances network biology by providing a versatile, accessible, and collaborative online platform that adapts to evolving computational challenges, laying a foundation for future incorporation of advanced network analysis capabilities by the community.

Indexed as

Computational BiologyGene Regulatory NetworksSoftwareAlgorithmsHumansInternetUser-Computer Interface

Identifiers

PMID40308211
PMCPMC12230733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.